Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase pim-2
Ligand
BDBM192546
Substrate
n/a
Meas. Tech.
ChEMBL_1622454 (CHEMBL3864806)
IC50
2.9±n/a nM
Citation
 Wurz, RP; Sastri, C; D'Amico, DC; Herberich, B; Jackson, CLM; Pettus, LH; Tasker, AS; Wu, B; Guerrero, N; Lipford, JR; Winston, JT; Yang, Y; Wang, P; Nguyen, Y; Andrews, KL; Huang, X; Lee, MR; Mohr, C; Zhang, JD; Reid, DL; Xu, Y; Zhou, Y; Wang, HL Discovery of imidazopyridazines as potent Pim-1/2 kinase inhibitors. Bioorg Med Chem Lett 26:5580-5590 (2016) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-2
Synonyms:
PIM2 | PIM2_HUMAN | Pim-2h | Serine/threonine-protein kinase (PIM2) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase pim-2 (PIM2)
Type:
Serine/threonine-protein kinase
Mol. Mass.:
34185.93
Organism:
Homo sapiens (Human)
Description:
Q9P1W9
Residue:
311
Sequence:
MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKGGPAPLAWSLLP
  
Inhibitor
Name:
BDBM192546
Synonyms:
US9187486, 8
Type:
Small organic molecule
Emp. Form.:
C19H20N8S
Mol. Mass.:
392.481
SMILES:
N[C@H]1CCCN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1nccs1 |r|
Structure:
Search PDB for entries with ligand similarity: