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Target
Polyunsaturated fatty acid lipoxygenase ALOX15
Ligand
BDBM50200541
Substrate
n/a
Meas. Tech.
ChEMBL_1622607 (CHEMBL3864959)
IC50
34000±n/a nM
Citation
 Morita, M; Naito, Y; Yoshikawa, T; Niki, E Inhibition of plasma lipid oxidation induced by peroxyl radicals, peroxynitrite, hypochlorite, 15-lipoxygenase, and singlet oxygen by clinical drugs. Bioorg Med Chem Lett 26:5411-5417 (2016) [PubMed]  Article 
Target
Name:
Polyunsaturated fatty acid lipoxygenase ALOX15
Synonyms:
Alox12l | Alox15 | Arachidonate 15-lipoxygenase | LOX15_MOUSE
Type:
PROTEIN
Mol. Mass.:
75439.28
Organism:
Mus musculus
Description:
ChEMBL_761404
Residue:
663
Sequence:
MGVYRIRVSTGDSVYAGSNNEVYLWLIGQHGEASLGKLFRPCRNSEAEFKVDVSEYLGPLLFVRVQKWHYLKEDAWFCNWISVKGPGDQGSEYTFPCYRWVQGTSILNLPEGTGCTVVEDSQGLFRNHREEELEERRSLYRWGNWKDGTILNVAATSISDLPVDQRFREDKRLEFEASQVLGTMDTVINFPKNTVTCWKSLDDFNYVFKSGHTKMAERVRNSWKEDAFFGYQFLNGANPMVLKRSTCLPARLVFPPGMEKLQAQLDEELKKGTLFEADFFLLDGIKANVILCSQQYLAAPLVMLKLQPDGQLLPIAIQLELPKTGSTPPPIFTPLDPPMDWLLAKCWVRSSDLQLHELQAHLLRGHLVAEVFAVATMRCLPSVHPVFKLLVPHLLYTMEINVRARSDLISERGFFDKVMSTGGGGHLDLLKQAGAFLTYSSLCPPDDLAERGLLDIDTCFYAKDALQLWQVMNRYVVGMFDLYYKTDQAVQDDYELQSWCQEITEIGLQGAQDRGFPTSLQSRAQACHFITMCIFTCTAQHSSIHLGQLDWFYWVPNAPCTMRLPPPKTKDATMEKLMATLPNPNQSTLQINVVWLLGRRQAVMVPLGQHSEEHFPNPEAKAVLKKFREELAALDKEIEIRNKSLDIPYEYLRPSLVENSVAI
  
Inhibitor
Name:
BDBM50200541
Synonyms:
CHEBI:31530 | Edaravone | MCI-186 | Radicava | Radicut
Type:
Small organic molecule
Emp. Form.:
C10H10N2O
Mol. Mass.:
174.1992
SMILES:
CC1=NN(C(=O)C1)c1ccccc1 |t:1|
Structure:
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