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Target
Proteasome subunit beta type-8
Ligand
BDBM50069989
Substrate
n/a
Meas. Tech.
ChEMBL_1622896 (CHEMBL3865248)
IC50
17±n/a nM
Citation
 Zhang, X; Adwal, A; Turner, AG; Callen, DF; Abell, AD New Peptidomimetic Boronates for Selective Inhibition of the Chymotrypsin-like Activity of the 26S Proteasome. ACS Med Chem Lett 7:1039-1043 (2016) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-8
Synonyms:
Lmp7 | Low molecular mass protein 7 | Macropain subunit C13 | Mc13 | Multicatalytic endopeptidase complex subunit C13 | PSB8_MOUSE | Proteasome component C13 | Proteasome subunit beta type-8 | Proteasome subunit beta-5i | Psmb8
Type:
PROTEIN
Mol. Mass.:
30260.37
Organism:
Mus musculus
Description:
ChEMBL_104442
Residue:
276
Sequence:
MALLDLCGAARGQRPEWAALDAGSGGRSDPGHYSFSAQAPELALPRGMQPTAFLRSFGGDQERNVQIEMAHGTTTLAFKFQHGVIVAVDSRATAGSYISSLRMNKVIEINPYLLGTMSGCAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMLQYRGMGLSMGSMICGWDKKGPGLYYVDDNGTRLSGQMFSTGSGNTYAYGVMDSGYRQDLSPEEAYDLGRRAIAYATHRDNYSGGVVNMYHMKEDGWVKVESSDVSDLLYKYGEAAL
  
Inhibitor
Name:
BDBM50069989
Synonyms:
(R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butylboronic acid | (R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-6-carboxamido)propanamido)butylboronic acid | BORTEZOMIB | CHEMBL325041 | Dipeptidyl boronic acid derivative | LDP-341 | N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE | PS-341 | Peptidyl boronic acid derivative | US11542283, Compound Velcade | Velcade | cid_387447
Type:
Small organic molecule
Emp. Form.:
C19H25BN4O4
Mol. Mass.:
384.237
SMILES:
CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnccn1)B(O)O |r|
Structure:
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