Reaction Details Report a problem with these data
Target
Complement factor D
Ligand
BDBM50201569
Substrate
n/a
Meas. Tech.
ChEMBL_1623115 (CHEMBL3865467)
IC50
77±n/a nM
Citation
 Yang, CY; Phillips, JG; Stuckey, JA; Bai, L; Sun, H; Delproposto, J; Brown, WC; Chinnaswamy, K Buried Hydrogen Bond Interactions Contribute to the High Potency of Complement Factor D Inhibitors. ACS Med Chem Lett 7:1092-1096 (2016) [PubMed]  Article 
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM50201569
Synonyms:
CHEMBL3924715
Type:
Small organic molecule
Emp. Form.:
C18H16BrN5O2S
Mol. Mass.:
446.321
SMILES:
Brc1cccc(NC(=O)[C@@H]2SCCN2C(=O)Cn2ncc3ccccc23)n1 |r|
Structure:
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