Reaction Details Report a problem with these data
Target
N-acetyltransferase Eis
Ligand
BDBM50201746
Substrate
n/a
Meas. Tech.
ChEMBL_1623397 (CHEMBL3865749)
IC50
250±n/a nM
Citation
 Garzan, A; Willby, MJ; Green, KD; Tsodikov, OV; Posey, JE; Garneau-Tsodikova, S Discovery and Optimization of Two Eis Inhibitor Families as Kanamycin Adjuvants against Drug-Resistant ACS Med Chem Lett 7:1219-1221 (2016) [PubMed]  Article 
Target
Name:
N-acetyltransferase Eis
Synonyms:
Aminoglycoside N-acetyltransferase | EIS_MYCTU | Enhanced intracellular survival protein | N-acetyltransferase Eis | Protein-lysine N-acetyltransferase | eis
Type:
PROTEIN
Mol. Mass.:
43803.37
Organism:
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Description:
ChEMBL_116995
Residue:
402
Sequence:
MTVTLCSPTEDDWPGMFLLAAASFTDFIGPESATAWRTLVPTDGAVVVRDGAGPGSEVVGMALYMDLRLTVPGEVVLPTAGLSFVAVAPTHRRRGLLRAMCAELHRRIADSGYPVAALHASEGGIYGRFGYGPATTLHELTVDRRFARFHADAPGGGLGGSSVRLVRPTEHRGEFEAIYERWRQQVPGGLLRPQVLWDELLAECKAAPGGDRESFALLHPDGYALYRVDRTDLKLARVSELRAVTADAHCALWRALIGLDSMERISIITHPQDPLPHLLTDTRLARTTWRQDGLWLRIMNVPAALEARGYAHEVGEFSTVLEVSDGGRFALKIGDGRARCTPTDAAAEIEMDRDVLGSLYLGAHRASTLAAANRLRTKDSQLLRRLDAAFASDVPVQTAFEF
  
Inhibitor
Name:
BDBM50201746
Synonyms:
CHEMBL3976122
Type:
Small organic molecule
Emp. Form.:
C16H12ClNO4
Mol. Mass.:
317.724
SMILES:
COC(=O)c1cc2occc2n1CC(=O)c1cccc(Cl)c1
Structure:
Search PDB for entries with ligand similarity: