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Target
N-acetyltransferase Eis
Ligand
BDBM50201755
Substrate
n/a
Meas. Tech.
ChEMBL_1623397 (CHEMBL3865749)
IC50
90±n/a nM
Citation
 Garzan, A; Willby, MJ; Green, KD; Tsodikov, OV; Posey, JE; Garneau-Tsodikova, S Discovery and Optimization of Two Eis Inhibitor Families as Kanamycin Adjuvants against Drug-Resistant ACS Med Chem Lett 7:1219-1221 (2016) [PubMed]  Article 
Target
Name:
N-acetyltransferase Eis
Synonyms:
Aminoglycoside N-acetyltransferase | EIS_MYCTU | Enhanced intracellular survival protein | N-acetyltransferase Eis | Protein-lysine N-acetyltransferase | eis
Type:
PROTEIN
Mol. Mass.:
43803.37
Organism:
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Description:
ChEMBL_116995
Residue:
402
Sequence:
MTVTLCSPTEDDWPGMFLLAAASFTDFIGPESATAWRTLVPTDGAVVVRDGAGPGSEVVGMALYMDLRLTVPGEVVLPTAGLSFVAVAPTHRRRGLLRAMCAELHRRIADSGYPVAALHASEGGIYGRFGYGPATTLHELTVDRRFARFHADAPGGGLGGSSVRLVRPTEHRGEFEAIYERWRQQVPGGLLRPQVLWDELLAECKAAPGGDRESFALLHPDGYALYRVDRTDLKLARVSELRAVTADAHCALWRALIGLDSMERISIITHPQDPLPHLLTDTRLARTTWRQDGLWLRIMNVPAALEARGYAHEVGEFSTVLEVSDGGRFALKIGDGRARCTPTDAAAEIEMDRDVLGSLYLGAHRASTLAAANRLRTKDSQLLRRLDAAFASDVPVQTAFEF
  
Inhibitor
Name:
BDBM50201755
Synonyms:
CHEMBL1410785
Type:
Small organic molecule
Emp. Form.:
C18H14FNO4
Mol. Mass.:
327.3065
SMILES:
Fc1ccc(cc1)C(=O)CN1C(=O)C2(OCCO2)c2ccccc12
Structure:
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