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Target
Indoleamine 2,3-dioxygenase 2
Ligand
BDBM48009
Substrate
n/a
Meas. Tech.
ChEMBL_1629928 (CHEMBL3872634)
Ki
3500±n/a nM
Citation
 Li, J; Li, Y; Yang, D; Hu, N; Guo, Z; Kuang, C; Yang, Q Establishment of a human indoleamine 2, 3-dioxygenase 2 (hIDO2) bioassay system and discovery of tryptanthrin derivatives as potent hIDO2 inhibitors. Eur J Med Chem 123:171-179 (2016) [PubMed]  Article 
Target
Name:
Indoleamine 2,3-dioxygenase 2
Synonyms:
I23O2_HUMAN | IDO-2 | IDO2 | INDOL1 | Indoleamine 2,3-dioxygenase-like protein 1 | Indoleamine-pyrrole 2,3-dioxygenase-like protein 1
Type:
PROTEIN
Mol. Mass.:
47079.13
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109909
Residue:
420
Sequence:
MLHFHYYDTSNKIMEPHRPNVKTAVPLSLESYHISEEYGFLLPDSLKELPDHYRPWMEIANKLPQLIDAHQLQAHVDKMPLLSCQFLKGHREQRLAHLVLSFLTMGYVWQEGEAQPAEVLPRNLALPFVEVSRNLGLPPILVHSDLVLTNWTKKDPDGFLEIGNLETIISFPGGESLHGFILVTALVEKEAVPGIKALVQATNAILQPNQEALLQALQRLRLSIQDITKTLGQMHDYVDPDIFYAGIRIFLSGWKDNPAMPAGLMYEGVSQEPLKYSGGSAAQSTVLHAFDEFLGIRHSKESGDFLYRMRDYMPPSHKAFIEDIHSAPSLRDYILSSGQDHLLTAYNQCVQALAELRSYHITMVTKYLITAAAKAKHGKPNHLPGPPQALKDRGTGGTAVMSFLKSVRDKTLESILHPRG
  
Inhibitor
Name:
BDBM48009
Synonyms:
8-fluoranylindolo[2,1-b]quinazoline-6,12-dione | 8-fluoroindolo[2,1-b]quinazoline-6,12-dione | 8-fluoroindolo[2,1-b]quinazoline-6,12-quinone | MLS001216278 | SMR000544298 | US10669273, Compound 5c | cid_478574
Type:
Small organic molecule
Emp. Form.:
C15H7FN2O2
Mol. Mass.:
266.2267
SMILES:
Fc1ccc-2c(c1)C(=O)c1nc3ccccc3c(=O)n-21
Structure:
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