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Target
Glutathione hydrolase 1 proenzyme
Ligand
BDBM50208437
Substrate
n/a
Meas. Tech.
ChEMBL_1632851 (CHEMBL3875643)
IC50
26300±n/a nM
Citation
 Mansha, M; Kumari, UU; Cournia, Z; Ullah, N Pyrazole-based potent inhibitors of GGT1: Synthesis, biological evaluation, and molecular docking studies. Eur J Med Chem 124:666-676 (2016) [PubMed]  Article 
Target
Name:
Glutathione hydrolase 1 proenzyme
Synonyms:
GGT | GGT1 | GGT1_HUMAN | Gamma-glutamyltranspeptidase 1
Type:
PROTEIN
Mol. Mass.:
61413.51
Organism:
Homo sapiens (Human)
Description:
ChEMBL_543160
Residue:
569
Sequence:
MKKKLVVLGLLAVVLVLVIVGLCLWLPSASKEPDNHVYTRAAVAADAKQCSKIGRDALRDGGSAVDAAIAALLCVGLMNAHSMGIGGGLFLTIYNSTTRKAEVINAREVAPRLAFATMFNSSEQSQKGGLSVAVPGEIRGYELAHQRHGRLPWARLFQPSIQLARQGFPVGKGLAAALENKRTVIEQQPVLCEVFCRDRKVLREGERLTLPQLADTYETLAIEGAQAFYNGSLTAQIVKDIQAAGGIVTAEDLNNYRAELIEHPLNISLGDVVLYMPSAPLSGPVLALILNILKGYNFSRESVESPEQKGLTYHRIVEAFRFAYAKRTLLGDPKFVDVTEVVRNMTSEFFAAQLRAQISDDTTHPISYYKPEFYTPDDGGTAHLSVVAEDGSAVSATSTINLYFGSKVRSPVSGILFNNEMDDFSSPSITNEFGVPPSPANFIQPGKQPLSSMCPTIMVGQDGQVRMVVGAAGGTQITTATALAIIYNLWFGYDVKRAVEEPRLHNQLLPNVTTVERNIDQAVTAALETRHHHTQIASTFIAVVQAIVRTAGGWAAASDSRKGGEPAGY
  
Inhibitor
Name:
BDBM50208437
Synonyms:
CHEMBL3884852
Type:
Small organic molecule
Emp. Form.:
C31H32Cl2FN5O3S
Mol. Mass.:
644.587
SMILES:
CSCCc1c(OCCCNC(=O)[C@H](Cc2ccc(F)cc2)NC(C)=O)n(nc1-c1cccnc1)-c1ccc(Cl)c(Cl)c1 |r|
Structure:
Search PDB for entries with ligand similarity: