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Target
Leukotriene A-4 hydrolase
Ligand
BDBM50210066
Substrate
n/a
Meas. Tech.
ChEMBL_1634260 (CHEMBL3877052)
IC50
>100000±n/a nM
Citation
 El-Naggar, MH; Mira, A; Abdel Bar, FM; Shimizu, K; Amer, MM; Badria, FA Synthesis, docking, cytotoxicity, and LTA Bioorg Med Chem 25:1277-1285 (2017) [PubMed]  Article 
Target
Name:
Leukotriene A-4 hydrolase
Synonyms:
LKHA4_HUMAN | LTA-4 hydrolase | LTA4 | LTA4H | Leukotriene A(4) hydrolase | Leukotriene A-4 hydrolase (LTA4H) | Leukotriene A4 hydrolase
Type:
Hydrolase; metalloprotease
Mol. Mass.:
69280.41
Organism:
Homo sapiens (Human)
Description:
Human recombinant LTA4H.
Residue:
611
Sequence:
MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDLTIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGETHPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAKEDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVTAMLVGKDLKVD
  
Inhibitor
Name:
BDBM50210066
Synonyms:
CHEMBL3884745
Type:
Small organic molecule
Emp. Form.:
C15H26O2
Mol. Mass.:
238.3657
SMILES:
[H][C@@]1([#6]-[#6]=[#6](-[#6])-[#6](-[#8])-[#6@H]1-[#8])[#6](-[#6])-[#6]-[#6]\[#6]=[#6](\[#6])-[#6] |r,t:3|
Structure:
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