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Target
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
Ligand
BDBM50217551
Substrate
n/a
Meas. Tech.
ChEMBL_178809 (CHEMBL784398)
IC50
>3000±n/a nM
Citation
 Pascal, Y; Andrianjara, CR; Auclair, E; Avenel, N; Bertin, B; Calvet, A; Féru, F; Lardon, S; Moodley, I; Ouagued, M; Payne, A; Pruniaux, MP; Szilagyi, C Synthesis and structure-activity relationships of 4-oxo-1-phenyl-3,4,6,7-tetrahydro-[1,4]diazepino[6,7,1-hi]indoles: novel PDE4 inhibitors. Bioorg Med Chem Lett 10:35-8 (2000) [PubMed]  Article 
Target
Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
Synonyms:
Dpde1 | PDE4C_RAT | Pde4c
Type:
PROTEIN
Mol. Mass.:
60038.21
Organism:
Rattus norvegicus
Description:
ChEMBL_104732
Residue:
536
Sequence:
NSSRTSSAASDLHGEDMIVTPFAQVLASLRTVRSNVAALAHGAGSATRQALLGTPPQSSQQAAPAEESGLQLAQETLEELDWCLEQLETLQTRRSVGEMASNKFKRMLNRELTHLSETSRSGNQVSEYISQTFLDQQAEVELPAPPTEDHPWPMAQITGLRKSCHTSLPTAAIPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAVIFRVLQERDLLKTFQIPADTLLRYLLTLEGHYHSNVAYHNSIHAADVVQSAHVLLGTPALEAVFTDLEVLAAIFACAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQGENCDIFQNLSTKQKLSLRRMVIDMVLATDMSKHMSLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQSLVHCADLSNPAKPLPLYRQWTERIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQELLDTLEDNREWYQSRVPCSPPHAIGPDRFKFELTLEETEEEEEEDERH
  
Inhibitor
Name:
BDBM50217551
Synonyms:
CHEMBL419791
Type:
Small organic molecule
Emp. Form.:
C25H19Cl2N3O2
Mol. Mass.:
464.343
SMILES:
Cc1cc2CCN3c2c(c1)C(=N[C@@H](NC(=O)c1ccc(Cl)cc1Cl)C3=O)c1ccccc1 |c:12|
Structure:
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