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Target
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
Ligand
BDBM50217546
Substrate
n/a
Meas. Tech.
ChEMBL_178809 (CHEMBL784398)
IC50
1090±n/a nM
Citation
 Pascal, Y; Andrianjara, CR; Auclair, E; Avenel, N; Bertin, B; Calvet, A; Féru, F; Lardon, S; Moodley, I; Ouagued, M; Payne, A; Pruniaux, MP; Szilagyi, C Synthesis and structure-activity relationships of 4-oxo-1-phenyl-3,4,6,7-tetrahydro-[1,4]diazepino[6,7,1-hi]indoles: novel PDE4 inhibitors. Bioorg Med Chem Lett 10:35-8 (2000) [PubMed]  Article 
Target
Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
Synonyms:
Dpde1 | PDE4C_RAT | Pde4c
Type:
PROTEIN
Mol. Mass.:
60038.21
Organism:
Rattus norvegicus
Description:
ChEMBL_104732
Residue:
536
Sequence:
NSSRTSSAASDLHGEDMIVTPFAQVLASLRTVRSNVAALAHGAGSATRQALLGTPPQSSQQAAPAEESGLQLAQETLEELDWCLEQLETLQTRRSVGEMASNKFKRMLNRELTHLSETSRSGNQVSEYISQTFLDQQAEVELPAPPTEDHPWPMAQITGLRKSCHTSLPTAAIPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAVIFRVLQERDLLKTFQIPADTLLRYLLTLEGHYHSNVAYHNSIHAADVVQSAHVLLGTPALEAVFTDLEVLAAIFACAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQGENCDIFQNLSTKQKLSLRRMVIDMVLATDMSKHMSLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQSLVHCADLSNPAKPLPLYRQWTERIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQELLDTLEDNREWYQSRVPCSPPHAIGPDRFKFELTLEETEEEEEEDERH
  
Inhibitor
Name:
BDBM50217546
Synonyms:
CHEMBL125123
Type:
Small organic molecule
Emp. Form.:
C26H23N7O2
Mol. Mass.:
465.5065
SMILES:
Cc1cc2nnc(C(=O)N[C@@H]3N=C(c4ccccc4)c4cc(C)cc5CCN(c45)C3=O)c(C)n2n1 |t:11|
Structure:
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