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Target
Putative penicillin-binding protein 2B
Ligand
BDBM50218772
Substrate
n/a
Meas. Tech.
ChEMBL_153519 (CHEMBL764472)
IC50
>567000±n/a nM
Citation
 Chen, Z; Demuth, TP; Wireko, FC Stereoselective synthesis and antibacterial evaluation of 4-amido-isothiazolidinone oxides. Bioorg Med Chem Lett 11:2111-5 (2001) [PubMed]  Article 
Target
Name:
Putative penicillin-binding protein 2B
Synonyms:
B9Z04_05970 | B9Z08_04335 | Cell division protein FtsI (Peptidoglycan synthetase) | EP54_05770 | EQ90_05620 | ERS072738_01739 | HMPREF3211_00860 | Penicillin-binding protein | Penicillin-binding protein 1 | Putative penicillin-binding protein 2B | Synonyms=ftsI_2 | pbp1 | pbpA
Type:
PROTEIN
Mol. Mass.:
82733.22
Organism:
Staphylococcus aureus
Description:
ChEMBL_105733
Residue:
744
Sequence:
MAKQKIKIKKNKIGAVLLVGLFGLLFFILVLRISYIMITGHSNGQDLVMKANEKYLVKNAQQPERGKIYDRNGKVLAEDVERYKLVAVIDKKASANSKKPRHVVDKKETAKKLSTVINMKPEEIEKRLSQKKAFQIEFGRKGTNLTYQDKLKIEKMNLPGISLLPETERFYPNGNFASHLIGRAQKNPDTGELKGALGVEKIFDSYLSGSKGSLRYIHDIWGYIAPNTKKEKQPKRGDDVHLTIDSNIQVFVEEALDGMVERYQPKDLFAVVMDAKTGEILAYSQRPTFNPETGKDFGKKWANDLYQNTYEPGSTFKSYGLAAAIQEGAFDPDKKYKSGHRDIMGSRISDWNRVGWGEIPMSLGFTYSSNTLMMHLQDLVGADKMKSWYERFGFGKSTKGMFDGEAPGQIGWSNELQQKTSSFGQSTTVTPVQMLQAQSAFFNDGNMLKPWFVNSVENPVSKRQFYKGQKQIAGKPITKDTAEKVEKQLDLVVNSKKSHAANYRIDGYEVEGKTGTAQVAAPNGGGYVKGPNPYFVSFMGDAPKKNPKVIVYAGMSLAQKNDQEAYELGVSKAFKPIMENTLKYLNVGKSKDDTSNAEYSKVPDVEGQDKQKAIDNVSAKSLEPVTIGSGTQIKAQSIKAGNKVLPHSKVLLLTDGDLTMPDMSGWTKEDVIAFENLTNIKVNLKGSGFVSHQSISKGQKLTEKDKIDVEFSSENVDSNSTNNSDSNSDDKKKSDSKTDKDKSD
  
Inhibitor
Name:
BDBM50218772
Synonyms:
CHEMBL66853
Type:
Small organic molecule
Emp. Form.:
C20H28N2O7S
Mol. Mass.:
440.511
SMILES:
CC(C)C(N1C(=O)C(CS1(=O)=O)NC(=O)OCc1ccccc1)C(=O)OC(C)(C)C
Structure:
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