Reaction Details Report a problem with these data
Target
Free fatty acid receptor 3
Ligand
BDBM50230295
Substrate
n/a
Meas. Tech.
ChEMBL_1644752 (CHEMBL3993681)
EC50
>10000±n/a nM
Citation
 Krasavin, M; Lukin, A; Bagnyukova, D; Zhurilo, N; Golovanov, A; Zozulya, S; Zahanich, I; Moore, D; Tikhonova, IG Polar aromatic periphery increases agonist potency of spirocyclic free fatty acid receptor (GPR40) agonists inspired by LY2881835. Eur J Med Chem 127:357-368 (2017) [PubMed]  Article 
Target
Name:
Free fatty acid receptor 3
Synonyms:
FFAR3 | FFAR3_HUMAN | GPR41
Type:
PROTEIN
Mol. Mass.:
38655.15
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1508992
Residue:
346
Sequence:
MDTGPDQSYFSGNHWFVFSVYLLTFLVGLPLNLLALVVFVGKLQRRPVAVDVLLLNLTASDLLLLLFLPFRMVEAANGMHWPLPFILCPLSGFIFFTTIYLTALFLAAVSIERFLSVAHPLWYKTRPRLGQAGLVSVACWLLASAHCSVVYVIEFSGDISHSQGTNGTCYLEFRKDQLAILLPVRLEMAVVLFVVPLIITSYCYSRLVWILGRGGSHRRQRRVAGLLAATLLNFLVCFGPYNVSHVVGYICGESPAWRIYVTLLSTLNSCVDPFVYYFSSSGFQADFHELLRRLCGLWGQWQQESSMELKEQKGGEEQRADRPAERKTSEHSQGCGTGGQVACAES
  
Inhibitor
Name:
BDBM50230295
Synonyms:
CHEMBL4098843
Type:
Small organic molecule
Emp. Form.:
C34H44Cl2N2O5
Mol. Mass.:
631.63
SMILES:
Cl.Cl.Cc1cccc(OCCC2CCOC3(CCN(Cc4ccc(COc5ccc(CCC(O)=O)cc5)cc4)CC3)C2)n1
Structure:
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