Reaction Details Report a problem with these data
Target
Atrial natriuretic peptide receptor 1
Ligand
BDBM50230984
Substrate
n/a
Meas. Tech.
ChEMBL_1645074 (CHEMBL3994003)
EC50
23±n/a nM
Citation
 Iwaki, T; Oyama, Y; Tomoo, T; Tanaka, T; Okamura, Y; Sugiyama, M; Yamaki, A; Furuya, M Discovery and dimeric approach of novel Natriuretic Peptide Receptor A (NPR-A) agonists. Bioorg Med Chem 25:1762-1769 (2017) [PubMed]  Article 
Target
Name:
Atrial natriuretic peptide receptor 1
Synonyms:
4.6.1.2 | ANP-A | ANPR-A | ANPRA_RAT | Atrial natriuretic peptide receptor 1 | Atrial natriuretic peptide receptor type A | GC-A | Guanylate cyclase A | NPR-A | Npr1
Type:
PROTEIN
Mol. Mass.:
118956.96
Organism:
Rattus norvegicus
Description:
ChEMBL_18039
Residue:
1057
Sequence:
MPGSRRVRPRLRALLLLPPLLLLRGGHASDLTVAVVLPLTNTSYPWSWARVGPAVELALARVKARPDLLPGWTVRMVLGSSENAAGVCSDTAAPLAAVDLKWEHSPAVFLGPGCVYSAAPVGRFTAHWRVPLLTAGAPALGIGVKDEYALTTRTGPSHVKLGDFVTALHRRLGWEHQALVLYADRLGDDRPCFFIVEGLYMRVRERLNITVNHQEFVEGDPDHYPKLLRAVRRKGRVIYICSSPDAFRNLMLLALNAGLTGEDYVFFHLDVFGQSLKSAQGLVPQKPWERGDGQDRSARQAFQAAKIITYKEPDNPEYLEFLKQLKLLADKKFNFTVEDGLKNIIPASFHDGLLLYVQAVTETLAQGGTVTDGENITQRMWNRSFQGVTGYLKIDRNGDRDTDFSLWDMDPETGAFRVVLNYNGTSQELMAVSEHKLYWPLGYPPPDVPKCGFDNEDPACNQDHFSTLEVLALVGSLSLISFLIVSFFIYRKMQLEKELVSELWRVRWEDLQPSSLERHLRSAGSRLTLSGRGSNYGSLLTTEGQFQVFAKTAYYKGNLVAVKRVNRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLESFRDPEPEQGHTLFAKKLWTAPELLRMASPPARGSQAGDVYSFGIILQEIALRSGVFYVEGLDLSPKEIIERVTRGEQPPFRPSMDLQSHLEELGQLMQRCWAEDPQERPPFQQIRLALRKFNKENSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGQLHAREVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFDGFELELRGDVEMKGKGKVRTYWLLGERGCSTRG
  
Inhibitor
Name:
BDBM50230984
Synonyms:
CHEMBL4099832
Type:
Small organic molecule
Emp. Form.:
C32H40F6N20O6
Mol. Mass.:
914.7808
SMILES:
OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.CCCCC1N(C(N)=NC1=O)c1nc(NC(N)=N)nc(Nc2ccc(Nc3nc(NC(N)=N)nc(n3)N3C(CCCC)C(=O)N=C3N)cc2)n1 |c:19,58|
Structure:
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