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Target
Protein mono-ADP-ribosyltransferase PARP12
Ligand
BDBM27135
Substrate
n/a
Meas. Tech.
ChEBML_1646313
IC50
58884±n/a nM
Citation
 Thorsell, AG; Ekblad, T; Karlberg, T; Löw, M; Pinto, AF; Trésaugues, L; Moche, M; Cohen, MS; Schüler, H Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors. J Med Chem 60:1262-1271 (2017) [PubMed]  Article 
Target
Name:
Protein mono-ADP-ribosyltransferase PARP12
Synonyms:
ADP-ribosyltransferase diphtheria toxin-like 12 | ARTD12 | PAR12_HUMAN | PARP-12 | PARP12 | Poly [ADP-ribose] polymerase 12 | ZC3HDC1 | Zinc finger CCCH domain-containing protein 1
Type:
PROTEIN
Mol. Mass.:
79092.00
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107665
Residue:
701
Sequence:
MAQAGVVGEVTQVLCAAGGALELPELRRRLRMGLSADALERLLRQRGRFVVAVRAGGAAAAPERVVLAASPLRLCRAHQGSKPGCVGLCAQLHLCRFMVYGACKFLRAGKNCRNSHSLTTEHNLSVLRTHGVDHLSYNELCQLLFQNDPWLLPEICQHYNKGDGPHGSCAFQKQCIKLHICQYFLQGECKFGTSCKRSHDFSNSENLEKLEKLGMSSDLVSRLPTIYRNAHDIKNKSSAPSRVPPLFVPQGTSERKDSSGSVSPNTLSQEEGDQICLYHIRKSCSFQDKCHRVHFHLPYRWQFLDRGKWEDLDNMELIEEAYCNPKIERILCSESASTFHSHCLNFNAMTYGATQARRLSTASSVTKPPHFILTTDWIWYWSDEFGSWQEYGRQGTVHPVTTVSSSDVEKAYLAYCTPGSDGQAATLKFQAGKHNYELDFKAFVQKNLVYGTTKKVCRRPKYVSPQDVTTMQTCNTKFPGPKSIPDYWDSSALPDPGFQKITLSSSSEEYQKVWNLFNRTLPFYFVQKIERVQNLALWEVYQWQKGQMQKQNGGKAVDERQLFHGTSAIFVDAICQQNFDWRVCGVHGTSYGKGSYFARDAAYSHHYSKSDTQTHTMFLARVLVGEFVRGNASFVRPPAKEGWSNAFYDSCVNSVSDPSIFVIFEKHQVYPEYVIQYTTSSKPSVTPSILLALGSLFSSRQ
  
Inhibitor
Name:
BDBM27135
Synonyms:
2-[(2R)-2-methylpyrrolidin-2-yl]-1H-1,3-benzodiazole-4-carboxamide | VELIPARIB | benzimidazole carboxamide, 3a
Type:
Small organic molecule
Emp. Form.:
C13H16N4O
Mol. Mass.:
244.2923
SMILES:
C[C@@]1(CCCN1)c1nc2cccc(C(N)=O)c2[nH]1 |r|
Structure:
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