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Target
Proteasome subunit beta type-10
Ligand
BDBM50232676
Substrate
n/a
Meas. Tech.
ChEMBL_1648458 (CHEMBL3997514)
IC50
>250000±n/a nM
Citation
 Johnson, HWB; Anderl, JL; Bradley, EK; Bui, J; Jones, J; Arastu-Kapur, S; Kelly, LM; Lowe, E; Moebius, DC; Muchamuel, T; Kirk, C; Wang, Z; McMinn, D Discovery of Highly Selective Inhibitors of the Immunoproteasome Low Molecular Mass Polypeptide 2 (LMP2) Subunit. ACS Med Chem Lett 8:413-417 (2017) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-10
Synonyms:
LMP10 | Low molecular mass protein 10 | MECL1 | Macropain subunit MECl-1 | Multicatalytic endopeptidase complex subunit MECl-1 | PSB10_HUMAN | PSMB10 | Proteasome MECl-1 | Proteasome subunit beta-2i
Type:
PROTEIN
Mol. Mass.:
28940.51
Organism:
Homo sapiens (Human)
Description:
ChEMBL_106197
Residue:
273
Sequence:
MLKPALEPRGGFSFENCQRNASLERVLPGLKVPHARKTGTTIAGLVFQDGVILGADTRATNDSVVADKSCEKIHFIAPKIYCCGAGVAADAEMTTRMVASKMELHALSTGREPRVATVTRILRQTLFRYQGHVGASLIVGGVDLTGPQLYGVHPHGSYSRLPFTALGSGQDAALAVLEDRFQPNMTLEAAQGLLVEAVTAGILGDLGSGGNVDACVITKTGAKLLRTLSSPTEPVKRSGRYHFVPGTTAVLTQTVKPLTLELVEETVQAMEVE
  
Inhibitor
Name:
BDBM50232676
Synonyms:
CHEMBL4101256
Type:
Small organic molecule
Emp. Form.:
C21H23N3O5
Mol. Mass.:
397.4244
SMILES:
C[C@H](NC(=O)c1cccc(=O)[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)[C@@]1(C)CO1 |r|
Structure:
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