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Target
D(3) dopamine receptor
Ligand
BDBM50424077
Substrate
n/a
Meas. Tech.
ChEMBL_1650511 (CHEMBL3999645)
Ki
1371±n/a nM
Citation
 Lee, DYW; Liu, J; Zhang, S; Huang, P; Liu-Chen, LY Asymmetric total synthesis of tetrahydroprotoberberine derivatives and evaluation of their binding affinities at dopamine receptors. Bioorg Med Chem Lett 27:1437-1440 (2017) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3
Type:
n/a
Mol. Mass.:
44243.43
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
400
Sequence:
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50424077
Synonyms:
(-)-Tetrahydropalmatine | L-Tetrahydropalmatine | TETRAHYDROPALMATINE
Type:
Small organic molecule
Emp. Form.:
C21H25NO4
Mol. Mass.:
355.4275
SMILES:
COc1cc2CCN3Cc4c(C[C@H]3c2cc1OC)ccc(OC)c4OC |r|
Structure:
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