Reaction Details Report a problem with these data
Target
Proteinase-activated receptor 2
Ligand
BDBM50412718
Substrate
n/a
Meas. Tech.
ChEMBL_1651136 (CHEMBL4000391)
EC50
300±n/a nM
Citation
 Yau, MK; Suen, JY; Xu, W; Lim, J; Liu, L; Adams, MN; He, Y; Hooper, JD; Reid, RC; Fairlie, DP Potent Small Agonists of Protease Activated Receptor 2. ACS Med Chem Lett 7:105-10 (2016) [PubMed]  Article 
Target
Name:
Proteinase-activated receptor 2
Synonyms:
F2RL1 | GPR11 | PAR2 | PAR2_HUMAN
Type:
PROTEIN
Mol. Mass.:
44152.54
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1497756
Residue:
397
Sequence:
MRSPSAAWLLGAAILLAASLSCSGTIQGTNRSSKGRSLIGKVDGTSHVTGKGVTVETVFSVDEFSASVLTGKLTTVFLPIVYTIVFVVGLPSNGMALWVFLFRTKKKHPAVIYMANLALADLLSVIWFPLKIAYHIHGNNWIYGEALCNVLIGFFYGNMYCSILFMTCLSVQRYWVIVNPMGHSRKKANIAIGISLAIWLLILLVTIPLYVVKQTIFIPALNITTCHDVLPEQLLVGDMFNYFLSLAIGVFLFPAFLTASAYVLMIRMLRSSAMDENSEKKRKRAIKLIVTVLAMYLICFTPSNLLLVVHYFLIKSQGQSHVYALYIVALCLSTLNSCIDPFVYYFVSHDFRDHAKNALLCRSVRTVKQMQVSLTSKKHSRKSSSYSSSSTTVKTSY
  
Inhibitor
Name:
BDBM50412718
Synonyms:
CHEMBL509819
Type:
Small organic molecule
Emp. Form.:
C36H63N11O8
Mol. Mass.:
777.9543
SMILES:
[#6]-[#6]-[#6@H](-[#6])-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#6])-[#6])-[#7]-[#6](=O)-c1ccco1)-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#7])-[#6](-[#7])=O |r|
Structure:
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