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Target
Casein kinase I isoform gamma-3
Ligand
BDBM50234169
Substrate
n/a
Meas. Tech.
ChEMBL_1652347 (CHEMBL4001602)
IC50
460±n/a nM
Citation
 Terstiege, I; Perry, M; Petersen, J; Tyrchan, C; Svensson, T; Lindmark, H; ึster, L Discovery of triazole aminopyrazines as a highly potent and selective series of PI3Kd inhibitors. Bioorg Med Chem Lett 27:679-687 (2017) [PubMed]  Article 
Target
Name:
Casein kinase I isoform gamma-3
Synonyms:
CSNK1G3 | KC1G3_HUMAN
Type:
PROTEIN
Mol. Mass.:
51411.12
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1440403
Residue:
447
Sequence:
MENKKKDKDKSDDRMARPSGRSGHNTRGTGSSSSGVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRKGYMFDYEYDWIGKQLPTPVGAVQQDPALSSNREAHQHRDKMQQSKNQSADHRAAWDSQQANPHHLRAHLAADRHGGSVQVVSSTNGELNTDDPTAGRSNAPITAPTEVEVMDETKCCCFFKRRKRKTIQRHK
  
Inhibitor
Name:
BDBM50234169
Synonyms:
CHEMBL4101902
Type:
Small organic molecule
Emp. Form.:
C23H20FN7O
Mol. Mass.:
429.4496
SMILES:
Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-c1ccc(C(N)=O)c(F)c1
Structure:
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