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Target
Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM50234710
Substrate
n/a
Meas. Tech.
ChEMBL_1653676 (CHEMBL4003042)
IC50
2560±n/a nM
Citation
 Miliutina, M; Ejaz, SA; Khan, SU; Iaroshenko, VO; Villinger, A; Iqbal, J; Langer, P Synthesis, alkaline phosphatase inhibition studies and molecular docking of novel derivatives of 4-quinolones. Eur J Med Chem 126:408-420 (2017) [PubMed]  Article 
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
ALPL | AP-TNAP | Alkaline phosphatase liver/bone/kidney isozyme | Alkaline phosphatase, tissue-nonspecific isozyme | PPBT_BOVIN | TNSALP | Tissue non-specific alkaline phosphatase (TNAP)
Type:
Protein
Mol. Mass.:
57195.60
Organism:
Bovine
Description:
P09487
Residue:
524
Sequence:
MISPFLLLAIGTCFASSLVPEKEKDPKYWRDQAQQTLKNALRLQTLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHSPGEETKLEMDKFPYVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATQRSQCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSASYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIKDIEVIMGGGRKYMFPKNRTDVEYELDEKARGTRLDGLNLIDIWKSFKPKHKHSHYVWNRTDLLALDPHSVDYLLGLFEPGDMQYELNRNNATDPSLSEMVEMAIRILNKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDQAIGQAGAMTSVEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMVSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFAKGPMAHLLHGVHEQNYIPHVMAYAACIGANRDHCASASSSGSPSPGPLLLLLALLPLGSLF
  
Inhibitor
Name:
BDBM50234710
Synonyms:
CHEMBL4084870
Type:
Small organic molecule
Emp. Form.:
C16H12N2O3
Mol. Mass.:
280.2781
SMILES:
Cc1ccc(cc1)-c1cc(=O)c2cc(ccc2[nH]1)[N+]([O-])=O
Structure:
Search PDB for entries with ligand similarity: