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Target
ADP-ribose pyrophosphatase, mitochondrial
Ligand
BDBM50236118
Substrate
n/a
Meas. Tech.
ChEMBL_1658777 (CHEMBL4008389)
IC50
>100000±n/a nM
Citation
 Llona-Minguez, S; Höglund, A; Wiita, E; Almlöf, I; Mateus, A; Calderón-Montaño, JM; Cazares-Körner, C; Homan, E; Loseva, O; Baranczewski, P; Jemth, AS; Häggblad, M; Martens, U; Lundgren, B; Artursson, P; Lundbäck, T; Jenmalm Jensen, A; Warpman Berglund, U; Scobie, M; Helleday, T Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1. J Med Chem 60:2148-2154 (2017) [PubMed]  Article 
Target
Name:
ADP-ribose pyrophosphatase, mitochondrial
Synonyms:
3.6.1.13 | ADP-ribose diphosphatase | ADP-ribose phosphohydrolase | ADP-ribose pyrophosphatase, mitochondrial | ADPR-PPase | Adenosine diphosphoribose pyrophosphatase | NUDT10 | NUDT10 | NUDT9 | NUDT9_HUMAN | Nucleoside diphosphate-linked moiety X motif 9 | Nudix motif 9
Type:
PROTEIN
Mol. Mass.:
39132.57
Organism:
Homo sapiens (Human)
Description:
ChEMBL_117589
Residue:
350
Sequence:
MAGRLLGKALAAVSLSLALASVTIRSSRCRGIQAFRNSFSSSWFHLNTNVMSGSNGSKENSHNKARTSPYPGSKVERSQVPNEKVGWLVEWQDYKPVEYTAVSVLAGPRWADPQISESNFSPKFNEKDGHVERKSKNGLYEIENGRPRNPAGRTGLVGRGLLGRWGPNHAADPIITRWKRDSSGNKIMHPVSGKHILQFVAIKRKDCGEWAIPGGMVDPGEKISATLKREFGEEALNSLQKTSAEKREIEEKLHKLFSQDHLVIYKGYVDDPRNTDNAWMETEAVNYHDETGEIMDNLMLEAGDDAGKVKWVDINDKLKLYASHSQFIKLVAEKRDAHWSEDSEADCHAL
  
Inhibitor
Name:
BDBM50236118
Synonyms:
CHEMBL4065181
Type:
Small organic molecule
Emp. Form.:
C15H12N4O2S2
Mol. Mass.:
344.411
SMILES:
COc1ccc(cc1OC)-c1nn2c(nnc2s1)-c1cccs1
Structure:
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