Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM50236679
Substrate
n/a
Meas. Tech.
ChEMBL_1661200 (CHEMBL4010812)
EC50
3920±n/a nM
Citation
 Li, H; Huang, Q; Chen, C; Xu, B; Wang, HY; Long, YQ Discovery of Potent and Orally Bioavailable GPR40 Full Agonists Bearing Thiophen-2-ylpropanoic Acid Scaffold. J Med Chem 60:2697-2717 (2017) [PubMed]  Article 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM50236679
Synonyms:
CHEMBL4073587
Type:
Small organic molecule
Emp. Form.:
C25H26O3S
Mol. Mass.:
406.537
SMILES:
Cc1cccc(C)c1-c1cccc(COc2ccc(s2)C(CC(O)=O)C2CC2)c1
Structure:
Search PDB for entries with ligand similarity: