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Target
Leukotriene A-4 hydrolase
Ligand
BDBM50082665
Substrate
n/a
Meas. Tech.
ChEMBL_1659615 (CHEMBL4009227)
IC50
680±n/a nM
Citation
 Lu, W; Yao, X; Ouyang, P; Dong, N; Wu, D; Jiang, X; Wu, Z; Zhang, C; Xu, Z; Tang, Y; Zou, S; Liu, M; Li, J; Zeng, M; Lin, P; Cheng, F; Huang, J Drug Repurposing of Histone Deacetylase Inhibitors That Alleviate Neutrophilic Inflammation in Acute Lung Injury and Idiopathic Pulmonary Fibrosis via Inhibiting Leukotriene A4 Hydrolase and Blocking LTB4 Biosynthesis. J Med Chem 60:1817-1828 (2017) [PubMed]  Article 
Target
Name:
Leukotriene A-4 hydrolase
Synonyms:
LKHA4_HUMAN | LTA-4 hydrolase | LTA4 | LTA4H | Leukotriene A(4) hydrolase | Leukotriene A-4 hydrolase (LTA4H) | Leukotriene A4 hydrolase
Type:
Hydrolase; metalloprotease
Mol. Mass.:
69280.41
Organism:
Homo sapiens (Human)
Description:
Human recombinant LTA4H.
Residue:
611
Sequence:
MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDLTIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGETHPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAKEDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVTAMLVGKDLKVD
  
Inhibitor
Name:
BDBM50082665
Synonyms:
4-(dimethylamino)-N-(7-(hydroxyamino)-7-oxoheptyl)benzamide | 4-Dimethylamino-N-(6-hydroxycarbamoyl-hexyl)-benzamide | CHEMBL140000 | US10188756, Compound CN52
Type:
Small organic molecule
Emp. Form.:
C16H25N3O3
Mol. Mass.:
307.388
SMILES:
CN(C)c1ccc(cc1)C(=O)NCCCCCCC(=O)NO
Structure:
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