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Target
Butyrophilin subfamily 3 member A1
Ligand
BDBM50236888
Substrate
n/a
Meas. Tech.
ChEMBL_1659718 (CHEMBL4009330)
EC50
>100000±n/a nM
Citation
 Shippy, RR; Lin, X; Agabiti, SS; Li, J; Zangari, BM; Foust, BJ; Poe, MM; Hsiao, CC; Vinogradova, O; Wiemer, DF; Wiemer, AJ Phosphinophosphonates and Their Tris-pivaloyloxymethyl Prodrugs Reveal a Negatively Cooperative Butyrophilin Activation Mechanism. J Med Chem 60:2373-2382 (2017) [PubMed]  Article 
Target
Name:
Butyrophilin subfamily 3 member A1
Synonyms:
BT3A1_HUMAN | BTF5 | BTN3A1 | Butyrophilin subfamily 3 member A1 | CD_antigen=CD277
Type:
PROTEIN
Mol. Mass.:
57685.08
Organism:
Homo sapiens (Human)
Description:
ChEMBL_117363
Residue:
513
Sequence:
MKMASFLAFLLLNFRVCLLLLQLLMPHSAQFSVLGPSGPILAMVGEDADLPCHLFPTMSAETMELKWVSSSLRQVVNVYADGKEVEDRQSAPYRGRTSILRDGITAGKAALRIHNVTASDSGKYLCYFQDGDFYEKALVELKVAALGSDLHVDVKGYKDGGIHLECRSTGWYPQPQIQWSNNKGENIPTVEAPVVADGVGLYAVAASVIMRGSSGEGVSCTIRSSLLGLEKTASISIADPFFRSAQRWIAALAGTLPVLLLLLGGAGYFLWQQQEEKKTQFRKKKREQELREMAWSTMKQEQSTRVKLLEELRWRSIQYASRGERHSAYNEWKKALFKPADVILDPKTANPILLVSEDQRSVQRAKEPQDLPDNPERFNWHYCVLGCESFISGRHYWEVEVGDRKEWHIGVCSKNVQRKGWVKMTPENGFWTMGLTDGNKYRTLTEPRTNLKLPKPPKKVGVFLDYETGDISFYNAVDGSHIHTFLDVSFSEALYPVFRILTLEPTALTICPA
  
Inhibitor
Name:
BDBM50236888
Synonyms:
CHEMBL4097373
Type:
Small organic molecule
Emp. Form.:
C10H22O6P2
Mol. Mass.:
300.2256
SMILES:
COP(=O)(CC\C=C(/C)CO)CP(=O)(OC)OC
Structure:
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