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Target
Glutaminyl-peptide cyclotransferase
Ligand
BDBM50238918
Substrate
n/a
Meas. Tech.
ChEBML_1664530
IC50
940±n/a nM
Citation
 Li, M; Li, M; Li, M; Dong, Y; Dong, Y; Dong, Y; Yu, X; Yu, X; Yu, X; Li, Y; Li, Y; Li, Y; Zou, Y; Zou, Y; Zou, Y; Zheng, Y; Zheng, Y; Zheng, Y; He, Z; He, Z; He, Z; Liu, Z; Liu, Z; Liu, Z; Quan, J; Quan, J; Quan, J; Bu, X; Bu, X; Bu, X; Wu, H; Wu, H; Wu, H Synthesis and Evaluation of Diphenyl Conjugated Imidazole Derivatives as Potential Glutaminyl Cyclase Inhibitors for Treatment of Alzheimer's Disease. J Med Chem 60:6664-6677 (2017) [PubMed]  Article 
Target
Name:
Glutaminyl-peptide cyclotransferase
Synonyms:
Glutaminyl Cyclase | Glutaminyl cyclase (QC) | Glutaminyl-peptide cyclotransferase | Glutaminyl-peptide cyclotransferase precursor (QC) | Glutaminyl-tRNA cyclotransferase | Glutamyl cyclase (QC) | QPCT | QPCT_HUMAN
Type:
Enzyme
Mol. Mass.:
40877.05
Organism:
Homo sapiens (Human)
Description:
Q16769
Residue:
361
Sequence:
MAGGRHRRVVGTLHLLLLVAALPWASRGVSPSASAWPEEKNYHQPAILNSSALRQIAEGTSISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSFSNIISTLNPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLSLKTVSDSKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHGMDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYGGVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLHL
  
Inhibitor
Name:
BDBM50238918
Synonyms:
CHEMBL4102373
Type:
Small organic molecule
Emp. Form.:
C22H27N3O2
Mol. Mass.:
365.4687
SMILES:
COc1ccc(cc1OC)-c1cc(C)ccc1NCCCn1cnc(C)c1
Structure:
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