Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase 17B
Ligand
BDBM50238986
Substrate
n/a
Meas. Tech.
ChEMBL_1664709 (CHEMBL4014505)
IC50
3240±n/a nM
Citation
 Wang, S; Xu, L; Lu, YT; Liu, YF; Han, B; Liu, T; Tang, J; Li, J; Wu, J; Li, JY; Yu, LF; Yang, F Discovery of benzofuran-3(2H)-one derivatives as novel DRAK2 inhibitors that protect islet?-cells from apoptosis. Eur J Med Chem 130:195-208 (2017) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase 17B
Synonyms:
DRAK2 | ST17B_HUMAN | STK17B | Serine/threonine-protein kinase 17B | Serine/threonine-protein kinase 17B (STK17B)
Type:
Enzyme
Mol. Mass.:
42332.49
Organism:
Homo sapiens (Human)
Description:
O94768
Residue:
372
Sequence:
MSRRRFDCRSISGLLTTTPQIPIKMENFNNFYILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCPRVINLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELREIMGTPEYLAPEILNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQLATDFIQSLLVKNPEKRPTAEICLSHSWLQQWDFENLFHPEETSSSSQTQDHSVRSSEDKTSKSSCNGTCGDREDKENIPEDSSMVSKRFRFDDSLPNPHELVSDLLC
  
Inhibitor
Name:
BDBM50238986
Synonyms:
CHEMBL2253275
Type:
Small organic molecule
Emp. Form.:
C17H14O4
Mol. Mass.:
282.2907
SMILES:
CCOc1cc(\C=C2/Oc3ccccc3C2=O)ccc1O
Structure:
Search PDB for entries with ligand similarity: