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Target
Death-associated protein kinase 2
Ligand
BDBM50580
Substrate
n/a
Meas. Tech.
ChEMBL_1664713 (CHEMBL4014509)
IC50
3070±n/a nM
Citation
 Wang, S; Xu, L; Lu, YT; Liu, YF; Han, B; Liu, T; Tang, J; Li, J; Wu, J; Li, JY; Yu, LF; Yang, F Discovery of benzofuran-3(2H)-one derivatives as novel DRAK2 inhibitors that protect islet?-cells from apoptosis. Eur J Med Chem 130:195-208 (2017) [PubMed]  Article 
Target
Name:
Death-associated protein kinase 2
Synonyms:
DAP kinase 2 | DAP-kinase-related protein 1 | DAPK2 | DAPK2_HUMAN | DRP-1
Type:
PROTEIN
Mol. Mass.:
42900.09
Organism:
Homo sapiens (Human)
Description:
ChEMBL_774557
Residue:
370
Sequence:
MFQASMRSPNMEPFKQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVLHHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWITPVDNQQAMVRRESVVNLENFRKQYVRRRWKLSFSIVSLCNHLTRSLMKKVHLRPDEDLRNCESDTEEDIARRKALHPRRRSSTS
  
Inhibitor
Name:
BDBM50580
Synonyms:
(2Z)-2-(3,4-dihydroxybenzylidene)-6-hydroxy-coumaran-3-one | (2Z)-2-[(3,4-dihydroxyphenyl)methylidene]-6-hydroxy-1-benzofuran-3-one | (2Z)-2-[(3,4-dihydroxyphenyl)methylidene]-6-hydroxy-3-benzofuranone | (2Z)-2-[[3,4-bis(oxidanyl)phenyl]methylidene]-6-oxidanyl-1-benzofuran-3-one | MLS000863576 | SMR000440743 | SULFURETIN | cid_5281295
Type:
Small organic molecule
Emp. Form.:
C15H10O5
Mol. Mass.:
270.2369
SMILES:
Oc1ccc2C(=O)\C(Oc2c1)=C\c1ccc(O)c(O)c1
Structure:
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