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Target
Hexokinase-4
Ligand
BDBM50239047
Substrate
n/a
Meas. Tech.
ChEMBL_1664963 (CHEMBL4014759)
EC50
23.0±n/a nM
Citation
 Xu, J; Lin, S; Myers, RW; Addona, G; Berger, JP; Campbell, B; Chen, HS; Chen, Z; Eiermann, GJ; Elowe, NH; Farrer, BT; Feng, W; Fu, Q; Kats-Kagan, R; Kavana, M; Malkani, S; McMasters, DR; Mitra, K; Pachanski, MJ; Tong, X; Trujillo, ME; Xu, L; Zhang, B; Zhang, F; Zhang, R; Parmee, ER Novel, highly potent systemic glucokinase activators for the treatment of Type 2 Diabetes Mellitus. Bioorg Med Chem Lett 27:2069-2073 (2017) [PubMed]  Article 
Target
Name:
Hexokinase-4
Synonyms:
Gck | HXK4_RAT | Hexokinase type IV
Type:
PROTEIN
Mol. Mass.:
52101.81
Organism:
Rattus norvegicus
Description:
ChEMBL_1279785
Residue:
465
Sequence:
MLDDRARMEATKKEKVEQILAEFQLQEEDLKKVMSRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDLDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRMVDESSANPGQQLYEKIIGGKYMGELVRLVLLKLVDENLLFHGEASEQLRTRGAFETRFVSQVESDSGDRKQIHNILSTLGLRPSVTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPNCEITFIESEEGSGRGAALVSAVACKKACMLAQ
  
Inhibitor
Name:
BDBM50239047
Synonyms:
CHEMBL4078915
Type:
Small organic molecule
Emp. Form.:
C23H21N5O4S
Mol. Mass.:
463.509
SMILES:
CN1C(CCC1=O)c1cc2[nH]c(cc2cc1Oc1ccc(nc1)S(C)(=O)=O)-c1cnccn1
Structure:
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