Reaction Details Report a problem with these data
Target
Hexokinase-4
Ligand
BDBM50239046
Substrate
n/a
Meas. Tech.
ChEMBL_1664960 (CHEMBL4014756)
EC50
9.8±n/a nM
Citation
 Xu, J; Lin, S; Myers, RW; Addona, G; Berger, JP; Campbell, B; Chen, HS; Chen, Z; Eiermann, GJ; Elowe, NH; Farrer, BT; Feng, W; Fu, Q; Kats-Kagan, R; Kavana, M; Malkani, S; McMasters, DR; Mitra, K; Pachanski, MJ; Tong, X; Trujillo, ME; Xu, L; Zhang, B; Zhang, F; Zhang, R; Parmee, ER Novel, highly potent systemic glucokinase activators for the treatment of Type 2 Diabetes Mellitus. Bioorg Med Chem Lett 27:2069-2073 (2017) [PubMed]  Article 
Target
Name:
Hexokinase-4
Synonyms:
GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D
Type:
Enzyme
Mol. Mass.:
52175.81
Organism:
Homo sapiens (Human)
Description:
P35557
Residue:
465
Sequence:
MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
  
Inhibitor
Name:
BDBM50239046
Synonyms:
CHEMBL4068048
Type:
Small organic molecule
Emp. Form.:
C27H28N4O5S
Mol. Mass.:
520.6
SMILES:
CN1C(CCC1=O)c1cc2[nH]c(cc2cc1Oc1ccc(nc1)S(C)(=O)=O)-c1ccc(cn1)C(C)(C)O
Structure:
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