Reaction Details Report a problem with these data
Target
Heme oxygenase 1
Ligand
BDBM84834
Substrate
n/a
Meas. Tech.
Heme Oxygenase
pH
7.4000±0.0000
Temperature
298.1500±0.0000 K
IC50
>1.00e+5±n/a nM
Citation
 Roman, G; Rahman, MN; Vukomanovic, D; Jia, Z; Nakatsu, K; Szarek, WA Heme oxygenase inhibition by 2-oxy-substituted 1-azolyl-4-phenylbutanes: effect of variation of the azole moiety. X-ray crystal structure of human heme oxygenase-1 in complex with 4-phenyl-1-(1H-1,2,4-triazol-1-yl)-2-butanone. Chem Biol Drug Des 75:68-90 (2010) [PubMed]  Article 
Target
Name:
Heme oxygenase 1
Synonyms:
HSP32 | HMOX1_RAT | Hmox1 | Heme Oxygenase 1 (HO-1) | Heme oxygenase 1
Type:
Enzyme
Mol. Mass.:
33005.15
Organism:
Rat
Description:
HO-1 obtained from rat spleen was used in enzyme assays.
Residue:
289
Sequence:
MERPQLDSMSQDLSEALKEATKEVHIRAENSEFMRNFQKGQVSREGFKLVMASLYHIYTALEEEIERNKQNPVYAPLYFPEELHRRAALEQDMAFWYGPHWQEAIPYTPATQHYVKRLHEVGGTHPELLVAHAYTRYLGDLSGGQVLKKIAQKAMALPSSGEGLAFFTFPSIDNPTKFKQLYRARMNTLEMTPEVKHRVTEEAKTAFLLNIELFEELQALLTEEHKDQSPSQTEFLRQRPASLVQDTTSAETPRGKSQISTSSSQTPLLRWVLTLSFLLATVAVGIYAM
  
Inhibitor
Name:
BDBM84834
Synonyms:
1-azolyl-4-phenyl-2-butanone, 36
Type:
n/a
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
Brc1nc(Br)n(CC(=O)CCc2ccccc2)n1
Structure:
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