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Target
5-hydroxytryptamine receptor 2A
Ligand
BDBM84938
Substrate
n/a
Ki
153±n/a nM
Comments
PDSP_1133
Citation
 Nelson, DL; Lucaites, VL; Audia, JE; Nissen, JS; Wainscott, DB Species differences in the pharmacology of the 5-hydroxytryptamine2 receptor: structurally specific differentiation by ergolines and tryptamines. J Pharmacol Exp Ther 265:1272-9 (1993) [PubMed] 
Target
Name:
5-hydroxytryptamine receptor 2A
Synonyms:
5-HT2 | 5HT2A_MACMU | HTR2A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
52607.65
Organism:
Monkey
Description:
5-HT2 0 Monkey::P50128
Residue:
471
Sequence:
MDILCEENTSLSSTTNSLMQLNEDTRLYSNDFNSGEANTSDAFNWTVESENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHRDPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEDASKDNSDGVNEKVSCV
  
Inhibitor
Name:
BDBM84938
Synonyms:
(6aR)-7-Methyl-4-isobutyl-4,6,6a真真,7,8,9,10,10a真真-octahydroindolo[4,3-fg]quinoline-9真真-carboxylic acid 2-hydroxy-1-methylpropyl ester 6-Methyl-1-(2-methylpropyl)ergoline-8真真-carboxylic acid 2-hydroxy-1-methylpropyl ester | (6aR)-7-Methyl-4-isobutyl-4,6,6a留,7,8,9,10,10a硫-octahydroindolo[4,3-fg]quinoline-9留-carboxylic acid 2-hydroxy-1-methylpropyl ester 6-Methyl-1-(2-methylpropyl)ergoline-8硫-carboxylic acid 2-hydroxy-1-methylpropyl ester | LY 197541 | LY-197541
Type:
Small organic molecule
Emp. Form.:
C24H34N2O3
Mol. Mass.:
398.5384
SMILES:
CC(C)Cn1cc2C[C@@H]3[C@H](C[C@H](CN3C)C(=O)OC(C)C(C)O)c3cccc1c23
Structure:
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