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Target
5-hydroxytryptamine receptor 2A
Ligand
BDBM84942
Substrate
n/a
Ki
10.9±n/a nM
Comments
PDSP_1705
Citation
 Nelson, DL; Lucaites, VL; Audia, JE; Nissen, JS; Wainscott, DB Species differences in the pharmacology of the 5-hydroxytryptamine2 receptor: structurally specific differentiation by ergolines and tryptamines. J Pharmacol Exp Ther 265:1272-9 (1993) [PubMed] 
Target
Name:
5-hydroxytryptamine receptor 2A
Synonyms:
5-HT-2A | 5-HT2 | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_RAT | Htr2 | Htr2a | Serotonin Receptor 2A
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52852.05
Organism:
Rattus norvegicus (rat)
Description:
Rat cortex membranes 5-HT2A receptors.
Residue:
471
Sequence:
MEILCEDNISLSSIPNSLMQLGDGPRLYHNDFNSRDANTSEASNWTIDAENRTNLSCEGYLPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAIWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPALAYKSSQLQVGQKKNSQEDAEQTVDDCSMVTLGKQQSEENCTDNIETVNEKVSCV
  
Inhibitor
Name:
BDBM84942
Synonyms:
CAS_108674-86-8 | NSC_60262 | Sergolexole
Type:
Small organic molecule
Emp. Form.:
C26H36N2O3
Mol. Mass.:
424.5756
SMILES:
COC1CCC(CC1)OC(=O)C1CC2C(Cc3cn(C(C)C)c4cccc2c34)N(C)C1 |(1.08,-14.15,;-.25,-13.38,;-.25,-11.84,;1.09,-11.07,;1.09,-9.53,;-.24,-8.76,;-1.58,-9.53,;-1.58,-11.07,;-.24,-7.22,;-1.58,-6.45,;-2.91,-7.22,;-1.57,-4.91,;-.24,-4.14,;-.24,-2.6,;-1.57,-1.83,;-1.57,-.29,;-.24,.48,;.32,2.08,;1.86,2.08,;2.75,3.34,;2.1,4.74,;4.28,3.2,;2.43,.48,;3.76,-.29,;3.76,-1.83,;2.43,-2.6,;1.09,-1.83,;1.09,-.29,;-2.9,-2.6,;-4.24,-1.83,;-2.91,-4.14,)|
Structure:
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