Reaction Details Report a problem with these data
Target
Gamma-aminobutyric acid receptor subunit alpha-6
Ligand
BDBM50017320
Substrate
n/a
Ki
12.7±n/a nM
Comments
PDSP_415
Citation
 Hadingham, KL; Garrett, EM; Wafford, KA; Bain, C; Heavens, RP; Sirinathsinghji, DJ; Whiting, PJ Cloning of cDNAs encoding the human gamma-aminobutyric acid type A receptor alpha 6 subunit and characterization of the pharmacology of alpha 6-containing receptors. Mol Pharmacol 49:253-9 (1996) [PubMed] 
Target
Name:
Gamma-aminobutyric acid receptor subunit alpha-6
Synonyms:
GABA A alpha6 | GABA receptor alpha-6 subunit | GABRA6 | GBRA6_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51029.60
Organism:
Homo sapiens (Human)
Description:
GABA A alpha6 0 HUMAN::Q16445
Residue:
453
Sequence:
MASSLPWLCIILWLENALGKLEVEGNFYSENVSRILDNLLEGYDNRLRPGFGGAVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWTDERLKFGGPTEILSLNNLMVSKIWTPDTFFRNGKKSIAHNMTTPNKLFRIMQNGTILYTMRLTINADCPMRLVNFPMDGHACPLKFGSYAYPKSEIIYTWKKGPLYSVEVPEESSSLLQYDLIGQTVSSETIKSNTGEYVIMTVYFHLQRKMGYFMIQIYTPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNLQTQKAKRKAQFAAPPTVTISKATEPLEAEIVLHPDSKYHLKKRITSLSLPIVSSSEANKVLTRAPILQSTPVTPPPLSPAFGGTSKIDQYSRILFPVAFAGFNLVYWVVYLSKDTMEVSSSVE
  
Inhibitor
Name:
BDBM50017320
Synonyms:
8-Bromo-7-oxo-3b,4,5,6-tetrahydro-7H-2,6a,11b-triaza-benzo[g]cyclopenta[e]azulene-3-carboxylic acid tert-butyl ester | Bretazenil | CHEMBL444045 | Ro-16-6028
Type:
Small organic molecule
Emp. Form.:
C19H20BrN3O3
Mol. Mass.:
418.284
SMILES:
CC(C)(C)OC(=O)c1ncn-2c1C1CCCN1C(=O)c1c(Br)cccc-21
Structure:
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