Reaction Details Report a problem with these data
Target
dCTP pyrophosphatase 1
Ligand
BDBM50241049
Substrate
n/a
Meas. Tech.
Enzyme Assay
pH
7.4±0
Temperature
298.15±0 K
Ki
1.68e+5± 1.7e+4 nM
Citation
 Corson, TW; Cavga, H; Aberle, N; Crews, CM Triptolide directly inhibits dCTP pyrophosphatase. Chembiochem 12:1767-73 (2011) [PubMed]  Article 
Target
Name:
dCTP pyrophosphatase 1
Synonyms:
DCTP1_HUMAN | DCTPP1 | Deoxycytidine-triphosphatase 1 | XTP3TPA | dCTP pyrophosphatase 1 | dCTP pyrophosphatase 1 (DCTPP1)
Type:
Protein
Mol. Mass.:
18673.58
Organism:
Homo sapiens (Human)
Description:
Q9H773
Residue:
170
Sequence:
MSVAGGEIRGDTGGEDTAAPGRFSFSPEPTLEDIRRLHAEFAAERDWEQFHQPRNLLLALVGEVGELAELFQWKTDGEPGPQGWSPRERAALQEELSDVLIYLVALAARCRVDLPLAVLSKMDINRRRYPAHLARSSSRKYTELPHGAISEDQAVGPADIPCDSTGQTST
  
Inhibitor
Name:
BDBM50241049
Synonyms:
CHEMBL463763 | Triptolide, 1 | triptolide
Type:
Small organic molecule
Emp. Form.:
C20H24O6
Mol. Mass.:
360.401
SMILES:
CC(C)[C@]12O[C@H]1[C@@H]1O[C@]11[C@]3(O[C@H]3C[C@H]3C4=C(CC[C@]13C)C(=O)OC4)[C@@H]2O |r,c:17|
Structure:
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