Reaction Details Report a problem with these data
Target
Melatonin receptor type 1B
Ligand
BDBM50043287
Substrate
n/a
Ki
0.11±n/a nM
Comments
PDSP_1190
Citation
 Nonno, R; Pannacci, M; Lucini, V; Angeloni, D; Fraschini, F; Stankov, BM Ligand efficacy and potency at recombinant human MT2 melatonin receptors: evidence for agonist activity of some mt1-antagonists. Br J Pharmacol 127:1288-94 (1999) [PubMed]  Article 
Target
Name:
Melatonin receptor type 1B
Synonyms:
MTNR1B | MTR1B_HUMAN | Mel-1B-R | Mel1b melatonin receptor | Melatonin 1B | Melatonin receptor | Melatonin receptor type 1B | Melatonin receptor type 2 (MT2)
Type:
Enzyme
Mol. Mass.:
40203.54
Organism:
Homo sapiens (Human)
Description:
P49286
Residue:
362
Sequence:
MSENGSFANCCEAGGWAVRPGWSGAGSARPSRTPRPPWVAPALSAVLIVTTAVDVVGNLLVILSVLRNRKLRNAGNLFLVSLALADLVVAFYPYPLILVAIFYDGWALGEEHCKASAFVMGLSVIGSVFNITAIAINRYCYICHSMAYHRIYRRWHTPLHICLIWLLTVVALLPNFFVGSLEYDPRIYSCTFIQTASTQYTAAVVVIHFLLPIAVVSFCYLRIWVLVLQARRKAKPESRLCLKPSDLRSFLTMFVVFVIFAICWAPLNCIGLAVAINPQEMAPQIPEGLFVTSYLLAYFNSCLNAIVYGLLNQNFRREYKRILLALWNPRHCIQDASKGSHAEGLQSPAPPIIGVQHQADAL
  
Inhibitor
Name:
BDBM50043287
Synonyms:
CHEMBL33415 | Melatonin,2-Bromo | N-[2-(2-Bromo-5-methoxy-1H-indol-3-yl)-ethyl]-acetamide | N-[2-(2-Bromo-5-methoxy-1H-indol-3-yl)-ethyl]-acetamide(2-Bromomelatonin)
Type:
Small organic molecule
Emp. Form.:
C13H15BrN2O2
Mol. Mass.:
311.174
SMILES:
COc1ccc2[nH]c(Br)c(CCNC(C)=O)c2c1
Structure:
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