Reaction Details Report a problem with these data
Target
Carbonic anhydrase 4
Ligand
BDBM10886
Substrate
n/a
Meas. Tech.
CA Assay
pH
7.4000±0.0000
Temperature
293.1500±0.0000 K
Ki
12±0.0 nM
Citation
 Supuran, CT; Scozzafava, A Benzolamide is not a membrane-impermeant carbonic anhydrase inhibitor. J Enzyme Inhib Med Chem 19:269-73 (2004) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 4
Synonyms:
Carbonic anhydrase 4 (CA IV) | Carbonic anhydrase IV (CA IV) | CA-IV | Carbonate dehydratase IV | CAH4_HUMAN | CA4 | Carbonic anhydrase
Type:
Enzyme
Mol. Mass.:
35037.98
Organism:
Human
Description:
P22748
Residue:
312
Sequence:
MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR
  
Inhibitor
Name:
BDBM10886
Synonyms:
BZA1 | CHEMBL73962 | 2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | Benzolamide (BZA) | Benzolamide
Type:
Small organic molecule
Emp. Form.:
C8H8N4O4S3
Mol. Mass.:
319.97
SMILES:
c1ccc(cc1)S(=O)(=O)Nc2nnc(s2)S(=O)(=O)N
Structure:
Search PDB for entries with ligand similarity: