Ki Summary

Reaction Details

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Target

Neurotensin receptor type 2

Ligand

BDBM85844

Substrate

n/a

17±n/a nM

Comments

PDSP_3752

Citation

Pettibone, DJ; Hess, JF; Hey, PJ; Jacobson, MA; Leviten, M; Lis, EV; Mallorga, PJ; Pascarella, DM; Snyder, MA; Williams, JB; Zeng, Z The effects of deleting the mouse neurotensin receptor NTR1 on central and peripheral responses to neurotensin. J Pharmacol Exp Ther 300:305-13 (2002) [PubMed] Article

More Info.:

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Target

Name:

Neurotensin receptor type 2

Synonyms:

NTR2_MOUSE | Neurotensin 2 | Neurotensin receptor type 2 | Ntsr2

Type:

Enzyme Catalytic Domain

Mol. Mass.:

46391.18

Organism:

MOUSE

Description:

P70310

Residue:

416

Sequence:

METSSLWPPRPSPSAGLSLEARLGVDTRLWAKVLFTALYSLIFALGTAGNALSVHVVLKARAGRPGRLRYHVLSLALSALLLLLISVPMELYNFVWSHYPWVFGDLGCRGYYFVRELCAYATVLSVASLSAERCLAVCQPLRARRLLTPRRTRRLLSLVWVASLGLALPMAVIMGQKHEMERADGEPEPASRVCTVLVSRATLQVFIQVNVLVSFVLPLALTAFLNGITVNHLVALYSQVPSASAQVNSIPSRLELLSEEGLLGFITWRKTLSLGVQASLVRHKDASQIRSLQHSAQVLRAIVAVYVICWLPYHARRLMYCYIPDDGWTDELYDFYHYFYMVTNTLFYVSSAVTPVLYNAVSSSFRKLFLESLSSLCGEQRSVVPLPQEAPESTTSTYSFRLWGSPRNPSLGEIQV

Inhibitor

Name:

BDBM85844

Synonyms:

CAS_54385 | Levocabastine | NSC_54385

Type:

Small organic molecule

Emp. Form.:

C26H29FN2O2

Mol. Mass.:

420.5191

SMILES:

CC1CN(CCC1(C(O)=O)c1ccccc1)C1CCC(CC1)(C#N)c1ccc(F)cc1 |(1.11,-6.21,;-.22,-6.98,;-.22,-8.52,;-1.56,-9.29,;-2.89,-8.52,;-2.89,-6.98,;-1.56,-6.21,;-.84,-4.85,;-.73,-3.31,;.7,-4.8,;-2.28,-4.85,;-3.82,-4.8,;-4.54,-3.44,;-3.73,-2.13,;-2.19,-2.18,;-1.47,-3.54,;-1.56,-10.83,;-2.89,-11.6,;-2.89,-13.14,;-1.56,-13.91,;-.22,-13.14,;-.22,-11.6,;-2.28,-15.27,;-3,-16.63,;-.84,-15.27,;.7,-15.32,;1.43,-16.68,;.61,-17.99,;1.33,-19.35,;-.93,-17.93,;-1.65,-16.57,)|

Structure: