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Target
Metabotropic glutamate receptor 2
Ligand
BDBM277127
Substrate
n/a
Meas. Tech.
Biological Assays
IC50
11000±n/a nM
Citation
 Arasappan, A; Bungard, CJ; Frie, JL; Han, Y; Hoyt, SB; Manley, PJ; Meissner, RS; Perkins, JJ; Sebhat, IK; Wilkening, RR; Leavitt, KJ Tetrahydronaphthyridine derivatives as mGluR2-negative allosteric modulators, compositions, and their use US Patent  US10072003 Publication Date 9/11/2018 
Target
Name:
Metabotropic glutamate receptor 2
Synonyms:
GPRC1B | GRM2 | GRM2_HUMAN | MGLUR2 | Metabotropic glutamate receptor | glutamate receptor, metabotropic 2 precursor | mGlu2 | metabotropic glutamate 2
Type:
Enzyme
Mol. Mass.:
95584.88
Organism:
Homo sapiens (Human)
Description:
Q14416
Residue:
872
Sequence:
MGSLLALLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASDGWGALESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAARASSSLGQGSGSQFVPTVCNGREVVDSTTSSL
  
Inhibitor
Name:
BDBM277127
Synonyms:
4-(4-chloro-2,6-difluorophenyl)-7-{[1- (difluoromethyl)-1H-pyrazol-5-yl]methyl}- 5,6,7,8-tetrahydro-1,7-naphthyridine-2- carboxamide | US10072003, Example 2-20
Type:
Small organic molecule
Emp. Form.:
C20H16ClF4N5O
Mol. Mass.:
453.821
SMILES:
NC(=O)c1cc(c2CCN(Cc3ccnn3C(F)F)Cc2n1)-c1c(F)cc(Cl)cc1F |(6.52,3.08,;5.19,3.85,;5.19,5.39,;3.85,3.08,;3.85,1.54,;2.52,.77,;1.18,1.54,;-.15,.77,;-1.48,1.54,;-1.48,3.08,;-2.82,3.85,;-4.15,3.08,;-5.61,3.56,;-6.52,2.31,;-5.61,1.06,;-4.15,1.54,;-3.06,.45,;-3.46,-1.04,;-1.57,.85,;-.15,3.85,;1.18,3.08,;2.52,3.85,;2.52,-.77,;1.18,-1.54,;-.15,-.77,;1.18,-3.08,;2.52,-3.85,;2.52,-5.39,;3.85,-3.08,;3.85,-1.54,;5.19,-.77,)|
Structure:
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