Ki Summary

Reaction Details

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Target

Vasoactive intestinal polypeptide receptor 2

Ligand

BDBM85872

Substrate

n/a

3.4±n/a nM

Comments

PDSP_2139

Citation

Igarashi, H; Ito, T; Pradhan, TK; Mantey, SA; Hou, W; Coy, DH; Jensen, RT Elucidation of the vasoactive intestinal peptide pharmacophore for VPAC(2) receptors in human and rat and comparison to the pharmacophore for VPAC(1) receptors. J Pharmacol Exp Ther 303:445-60 (2002) [PubMed] Article

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Target

Name:

Vasoactive intestinal polypeptide receptor 2

Synonyms:

VIP 2 | VIPR2_RAT | Vipr2

Type:

Enzyme Catalytic Domain

Mol. Mass.:

49559.72

Organism:

RAT

Description:

VIP 2 VIPR2 RAT::P35000

Residue:

437

Sequence:

MRASVVLTCYCWLLVRVSSIHPECRFHLEIQEEETKCAELLSSQMENHRACSGVWDNITCWRPADIGETVTVPCPKVFSNFYSRPGNISKNCTSDGWSETFPDFIDACGYNDPEDESKITFYILVKAIYTLGYSVSLMSLTTGSIIICLFRKLHCTRNYIHLNLFLSFMLRAISVLVKDSVLYSSSGTLRCHDQPGSWVGCKLSLVFFQYCIMANFYWLLVEGLYLHTLLVAILPPSRCFLAYLLIGWGIPSVCIGAWIATRLSLEDTGCWDTNDHSIPWWVIRMPILISIVVNFALFISIVRILLQKLTSPDVGGNDQSQYKRLAKSTLLLIPLFGVHYMVFAAFPIGISSTYQILFELCVGSFQGLVVAVLYCFLNSEVQCELKRRWRGLCLTQPGSRDYRLHSWSMSRNGSESALQIHRGSRTQSFLQSETSVI

Inhibitor

Name:

BDBM85872

Synonyms:

VIP Ala19

Type:

Small organic molecule

Emp. Form.:

C145H234N44O42S

Mol. Mass.:

3297.744

SMILES:

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Structure: