Reaction Details Report a problem with these data
Target
Vasoactive intestinal polypeptide receptor 2
Ligand
BDBM85899
Substrate
n/a
Ki
7.2±n/a nM
Comments
PDSP_2145
Citation
 Igarashi, H; Ito, T; Pradhan, TK; Mantey, SA; Hou, W; Coy, DH; Jensen, RT Elucidation of the vasoactive intestinal peptide pharmacophore for VPAC(2) receptors in human and rat and comparison to the pharmacophore for VPAC(1) receptors. J Pharmacol Exp Ther 303:445-60 (2002) [PubMed]  Article 
Target
Name:
Vasoactive intestinal polypeptide receptor 2
Synonyms:
VIP 2 | VIPR2_RAT | Vipr2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49559.72
Organism:
RAT
Description:
VIP 2 VIPR2 RAT::P35000
Residue:
437
Sequence:
MRASVVLTCYCWLLVRVSSIHPECRFHLEIQEEETKCAELLSSQMENHRACSGVWDNITCWRPADIGETVTVPCPKVFSNFYSRPGNISKNCTSDGWSETFPDFIDACGYNDPEDESKITFYILVKAIYTLGYSVSLMSLTTGSIIICLFRKLHCTRNYIHLNLFLSFMLRAISVLVKDSVLYSSSGTLRCHDQPGSWVGCKLSLVFFQYCIMANFYWLLVEGLYLHTLLVAILPPSRCFLAYLLIGWGIPSVCIGAWIATRLSLEDTGCWDTNDHSIPWWVIRMPILISIVVNFALFISIVRILLQKLTSPDVGGNDQSQYKRLAKSTLLLIPLFGVHYMVFAAFPIGISSTYQILFELCVGSFQGLVVAVLYCFLNSEVQCELKRRWRGLCLTQPGSRDYRLHSWSMSRNGSESALQIHRGSRTQSFLQSETSVI
  
Inhibitor
Name:
BDBM85899
Synonyms:
VIP Ala25 | VIP Ala26
Type:
Small organic molecule
Emp. Form.:
C144H232N44O42S
Mol. Mass.:
3283.717
SMILES:
CSCC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)C(NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(C)C)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(N)=O |r,wU:103.105,88.89,112.118,137.141,72.77,126.128,140.144,37.41,17.22,4.4,151.153,167.169,188.191,204.207,215.218,wD:92.101,107.109,80.85,120.124,60.69,45.52,26.33,8.13,146.149,158.160,176.178,196.199,210.214,223.226,(12.13,4.79,;10.78,4.01,;10.78,2.48,;9.39,1.74,;9.39,.22,;7.99,-.48,;6.69,.22,;6.73,1.79,;5.34,-.48,;5.34,-2.05,;6.69,-2.83,;6.64,-4.36,;7.95,-5.14,;5.29,-5.1,;4.03,.26,;2.68,-.44,;2.64,-2,;1.33,.31,;1.33,1.83,;2.68,2.57,;2.68,4.14,;4.07,4.92,;4.07,6.49,;.02,-.39,;-1.24,.31,;-1.2,1.83,;-2.55,-.39,;-2.59,-2,;-1.24,-2.74,;-1.24,-4.27,;.02,-5.05,;.02,-6.58,;-1.24,-7.36,;1.33,-7.41,;-3.9,.31,;-5.25,-.39,;-5.25,-1.96,;-6.55,.31,;-6.55,1.87,;-5.25,2.61,;-5.25,4.14,;-3.9,1.87,;-7.91,-.39,;-9.26,.35,;-9.21,1.87,;-10.56,-.39,;-10.61,-1.96,;-9.26,-2.7,;-9.26,-4.27,;-7.91,-5.01,;-7.91,-6.58,;-9.26,-7.36,;-6.6,-7.36,;-11.91,.35,;-13.22,-.35,;-13.22,-1.96,;-14.57,.35,;-15.92,-.35,;-17.27,.35,;-17.23,1.92,;-18.62,-.35,;-18.62,-1.87,;-17.27,-2.7,;-17.27,-4.23,;-15.92,-4.97,;-14.57,-4.23,;-13.26,-5.01,;-14.57,-2.7,;-15.92,-1.96,;-19.93,.35,;-21.24,-.35,;-21.24,-1.87,;-22.59,.39,;-22.59,1.92,;-21.24,2.66,;-19.93,1.92,;-21.24,4.23,;-23.94,-.31,;-25.29,.39,;-25.29,1.92,;-26.64,-.31,;-26.64,-1.87,;-25.29,-2.66,;-23.94,-1.87,;-25.29,-4.18,;-27.9,.39,;-29.25,-.31,;-29.25,-1.83,;-30.6,.39,;-31.95,-.31,;-33.3,.44,;-33.3,1.96,;-34.61,-.31,;-34.61,-1.83,;-33.3,-2.61,;-33.3,-4.18,;-31.95,-4.92,;-30.6,-4.18,;-30.6,-2.66,;-31.95,-1.83,;-35.92,.44,;-37.27,-.22,;-37.27,-2,;-38.75,.52,;-40.23,-.22,;-41.53,.44,;-41.53,2,;-42.84,-.22,;-42.84,-1.79,;-44.19,.44,;-45.54,-.22,;-45.54,-1.79,;-46.89,.48,;-46.89,2,;-45.54,2.74,;-45.54,4.31,;-44.21,1.97,;-48.24,-.17,;-49.51,.48,;-49.51,2,;-50.86,-.17,;-50.86,-1.71,;-49.52,-2.48,;-52.16,.48,;-53.47,-.17,;-53.47,-1.79,;-54.82,.48,;-56.13,-.17,;-54.82,2.05,;-56.15,2.82,;-57.64,2.42,;-58.48,3.71,;-57.51,4.91,;-56.07,4.35,;-38.75,2.06,;-37.41,2.83,;-39.84,3.15,;-30.6,1.96,;-31.95,2.7,;-29.25,2.7,;-14.57,1.87,;-15.92,2.66,;-13.22,2.66,;10.74,-.52,;10.69,-2.09,;12.09,.17,;13.4,-.57,;13.4,-2.13,;14.75,.13,;14.79,1.7,;16.05,-.61,;17.4,.09,;17.45,1.66,;16.1,2.4,;18.8,2.4,;18.75,-.61,;18.71,-2.22,;20.1,.09,;21.41,-.65,;21.41,-2.22,;22.72,-3.01,;22.67,-4.57,;24.02,-5.36,;23.98,-6.93,;22.72,.04,;22.76,1.57,;24.07,-.7,;25.42,-0,;25.46,1.57,;26.81,2.27,;26.81,3.83,;28.21,4.57,;28.21,6.1,;26.72,-.74,;26.72,-2.31,;28.12,-.04,;29.38,-.78,;29.34,-2.35,;30.69,-3.14,;30.65,-4.7,;32,-5.53,;33.35,-4.75,;34.65,-5.58,;33.39,-3.22,;32.04,-2.44,;30.73,-.04,;30.78,1.44,;32.08,-.83,;33.43,-.09,;33.48,1.35,;34.83,2.09,;34.87,3.66,;36.09,1.26,;34.74,-.92,;34.74,-2.48,;36.09,-.13,;37.4,-.96,;37.35,-2.53,;38.7,-3.31,;40.05,-2.61,;38.66,-4.88,;38.75,-.17,;38.79,1.22,;40.1,-1,;41.45,-.31,;41.49,1.18,;42.84,1.92,;42.75,-1.05,;42.75,-2.66,;44.11,-.35,;45.41,-1.13,;45.37,-2.7,;46.76,-.39,;46.81,1.05,;48.11,-1.18,;49.46,-.44,;49.51,1,;50.81,1.79,;50.86,3.31,;52.12,.96,;50.73,-1.22,;50.73,-2.83,;52.12,-.52,;53.43,-1.31,;53.38,-2.87,;54.73,-3.7,;56.08,-2.92,;54.69,-5.23,;54.78,-.57,;56.13,-1.35,;54.82,.92,)|
Structure:
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