Reaction Details
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Report a problem with these dataTarget
Muscarinic acetylcholine receptor M5
Ligand
BDBM86198
Substrate
n/a
Ki
>10000±n/a nM
Comments
PDSP_2974
Citation
Shi, Q; Savage, JE; Hufeisen, SJ; Rauser, L; Grajkowska, E; Ernsberger, P; Wroblewski, JT; Nadeau, JH; Roth, BL L-homocysteine sulfinic acid and other acidic homocysteine derivatives are potent and selective metabotropic glutamate receptor agonists. J Pharmacol Exp Ther 305:131-42 (2003) [PubMed] Article More Info.:
Target
Name:
Muscarinic acetylcholine receptor M5
Synonyms:
ACM5_HUMAN | CHRM5
Type:
PROTEIN
Mol. Mass.:
60102.35
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1517990
Residue:
532
Sequence:
MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP
Inhibitor
Name:
BDBM86198
Synonyms:
CAS_134505 | L-homocysteine thiolactone | NSC_134505
Type:
Small organic molecule
Emp. Form.:
C4H7NOS
Mol. Mass.:
117.169
SMILES:
N[C@H]1CCSC1=O |r|
Structure:
