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Target
Neuronal acetylcholine receptor subunit alpha-6
Ligand
BDBM50004108
Substrate
n/a
Ki
20±n/a nM
Comments
PDSP_1311
Citation
 Vailati, S; Moretti, M; Longhi, R; Rovati, GE; Clementi, F; Gotti, C Developmental expression of heteromeric nicotinic receptor subtypes in chick retina. Mol Pharmacol 63:1329-37 (2003) [PubMed]  Article 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-6
Synonyms:
ACHA6_CHICK | CHRNA6 | Cholinergic, Nicotinic Alpha6
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57501.33
Organism:
Chick
Description:
Cholinergic, Nicotinic Alpha6 0 Chick::P49581
Residue:
494
Sequence:
MHPKRRLCWCLPASGAWAFMLTSLIADTTACESEERLFHKLFSRYNQFIRPVENVSDPVTVHFELAITQLTNVDEVNQIMETNLWLRHIWNDYKLRRDPREYDGIEFVRVPADKIWKPDIVLYNNAVGDFQVEGKTKALLRYDGMITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAKIDLLIIGSKVDMNEFWENSEWEIVDASGYKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLVGEYLLFTMIFVTLSIVITVFVLNIHYRTPTTHTMPKWVKTVFLSLLPKVLLMQRPLEQEKKNISKKTKKGSAKTSGKSKHSKHKDNKLHKEQRCCHCDKADDLTSTRRSRLSHQSLKWMAEHTEYSPEVKDVINNVQFIAENMKSQNETKEVEDDWKYVAMVIDRVFLWVFIILCVFGTAGLFIQPLIADT
  
Inhibitor
Name:
BDBM50004108
Synonyms:
(+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3-(1-methylpyrrolidin-2-yl)pyridine | CHEMBL440464 | Nicotin | Nicotine-(+) | Nikotin | US11667638, Example Nicotine | US8609708, 54 Nicotine | US9284322, Nicotine | US9993465, Nicotine | nicotine
Type:
Small organic molecule
Emp. Form.:
C10H14N2
Mol. Mass.:
162.2316
SMILES:
CN1CCCC1c1cccnc1
Structure:
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