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Target
Interleukin-8
Ligand
BDBM277689
Substrate
n/a
Meas. Tech.
PBMC Cell Assay
IC50
16.4±n/a nM
Citation
 Fyfe, MC; Thom, SM Kinase inhibitors US Patent  US10072034 Publication Date 9/11/2018 
Target
Name:
Interleukin-8
Synonyms:
CXCL8 | IL8 | IL8_HUMAN | MDNCF-a | interleukin 8 precursor
Type:
PROTEIN
Mol. Mass.:
11104.05
Organism:
Homo sapiens (Human)
Description:
ChEMBL_577736
Residue:
99
Sequence:
MTSKLAVALLAAFLISAALCEGAVLPRSAKELRCQCIKTYSKPFHPKFIKELRVIESGPHCANTEIIVKLSDGRELCLDPKENWVQRVVEKFLKRAENS
  
Inhibitor
Name:
BDBM277689
Synonyms:
2-(2-(2-(3-((4-((4-(3-(5-(tert-Butyl-3-(ethylsulfonyl)-2-methoxyphenyl)ureido)naphthalen-1-yl)oxy)pyridin-2-yl)amino)-5-methoxyphenyl)ethoxy)ethoxy)acetic acid | US10072034, Example 15
Type:
Small organic molecule
Emp. Form.:
C42H48N4O11S
Mol. Mass.:
816.916
SMILES:
CCS(=O)(=O)c1cc(cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4cc(OC)cc(OCCOCCOCC(O)=O)c4)c3)c3ccccc23)c1OC)C(C)(C)C
Structure:
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