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Target
Interleukin-8
Ligand
BDBM277694
Substrate
n/a
Meas. Tech.
PBMC Cell Assay
IC50
19.1±n/a nM
Citation
 Fyfe, MC; Thom, SM Kinase inhibitors US Patent  US10072034 Publication Date 9/11/2018 
Target
Name:
Interleukin-8
Synonyms:
CXCL8 | IL8 | IL8_HUMAN | MDNCF-a | interleukin 8 precursor
Type:
PROTEIN
Mol. Mass.:
11104.05
Organism:
Homo sapiens (Human)
Description:
ChEMBL_577736
Residue:
99
Sequence:
MTSKLAVALLAAFLISAALCEGAVLPRSAKELRCQCIKTYSKPFHPKFIKELRVIESGPHCANTEIIVKLSDGRELCLDPKENWVQRVVEKFLKRAENS
  
Inhibitor
Name:
BDBM277694
Synonyms:
US10072034, Example 20(a) | US10072034, Example 20(b)
Type:
Small organic molecule
Emp. Form.:
C42H49N5O11S
Mol. Mass.:
831.93
SMILES:
COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(OCCOCCOC(C)C(O)=O)c1 |w:53.57|
Structure:
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