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Target
Neuronal acetylcholine receptor subunit alpha-5
Ligand
BDBM86544
Substrate
n/a
Ki
991±n/a nM
Comments
PDSP_4100
Citation
 Grinevich, VP; Letchworth, SR; Lindenberger, KA; Menager, J; Mary, V; Sadieva, KA; Buhlman, LM; Bohme, GA; Pradier, L; Benavides, J; Lukas, RJ; Bencherif, M Heterologous expression of human {alpha}6{beta}4{beta}3{alpha}5 nicotinic acetylcholine receptors: binding properties consistent with their natural expression require quaternary subunit assembly including the {alpha}5 subunit. J Pharmacol Exp Ther 312:619-26 (2005) [PubMed]  Article 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-5
Synonyms:
ACHA5_RAT | Acra5 | Cholinergic, Nicotinic Alpha6Beta3Beta4Alpha5 | Chrna5
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51875.01
Organism:
RAT
Description:
Cholinergic, Nicotinic Alpha6Beta3Beta4Alpha5 0 RAT::P20420
Residue:
452
Sequence:
MVQLLAGRWRPTGARRGTRGGLPELSSAAKHEDSLFRDLFEDYERWVRPVEHLSDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQEWIDVKLRWNPDDYGGIKIIRVPSDSLWIPDIVLFDNADGRFEGASTKTVVRYNGTVTWTQPANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIILEDQDVDRTDFFDNGEWEIMSAMGSKGNRTDSCCWYPYITYSFVIKRLPLFYTLFLIIPCIGLSFLTVVVFYLPSNEGEKISLCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIHHRSSSTHNAMAPWVRKIFLHKLPKLLCMRSHADRYFTQREEAESGAGPKSRNTLEAALDCIRYITRHVVKENDVREVVEDWKFIAQVLDRMFLWTFLLVSIIGTLGLFVPVIYKWANIIVPVHIGNTIK
  
Inhibitor
Name:
BDBM86544
Synonyms:
CAS_192231-16-6 | CHEMBL111580 | NSC_6442277 | SIB-1508Y
Type:
Small organic molecule
Emp. Form.:
C12H14N2
Mol. Mass.:
186.253
SMILES:
CN1CCCC1c1cncc(c1)C#C
Structure:
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