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Target
Glutamine--fructose-6-phosphate transaminase (isomerizing)
Ligand
BDBM86764
Substrate
n/a
Meas. Tech.
Inhibition Assay
Ki
5.65e+4±n/a nM
IC50
2.70e+5± 3.0e+4 nM
Citation
 Jedrzejczak, R; Wojciechowski, M; Andruszkiewicz, R; Sowinski, P; Kot-Wasik, A; Milewski, S Inactivation of glucosamine-6-phosphate synthase by N3-oxoacyl derivatives of L-2,3-diaminopropanoic acid. Chembiochem 13:85-96 (2012) [PubMed]  Article 
Target
Name:
Glutamine--fructose-6-phosphate transaminase (isomerizing)
Synonyms:
Glucosamine-6-phosphate synthase
Type:
Enzyme
Mol. Mass.:
80044.29
Organism:
Saccharomyces cerevisiae (Baker's yeast)
Description:
A6ZZL3
Residue:
717
Sequence:
MCGIFGYCNYLVERSRGEIIDTLVDGLQRLEYRGYDSTGIAIDGDEADSTFIYKQIGKVSALKEEITKQNPNRDVTFVSHCGIAHTRWATHGRPEQVNCHPQRSDPEDQFVVVHNGIITNFRELKTLLINKGYKFESDTDTECIAKLYLHLYNTNLQNGHDLDFHELTKLVLLELEGSYGLLCKSCHYPNEVIATRKGSPLLIGVKSEKKLKVDFVDVEFPEENAGQPEIPLKSNNKSFGLGPKKAREFEAGSQNANLLPIAANEFNLRHSQSRAFLSEDGSPTPVEFFVSSDAASVVKHTKKVLFLEDDDLAHIYDGELHIHRSRREVGASMTRSIQTLEMELAQIMKGPYDHFMQKEIYEQPESTFNTMRGRIDYENNKVILGGLKAWLPVVRRARRLIMIACGTSYHSCLATRAIFEELSDIPVSVELASDFLDRKCPVFRDDVCVFVSQSGETADTMLALNYCLERGALTVGIVNSVGSSISRVTHCGVHINAGPEIGVASTKAYTSQYIALVMFALSLSDDRVSKIDRRIEIIQGLKLIPGQIKQVLKLEPRIKKLCATELKDQKSLLLLGRGYQFAAALEGALKIKEISYMHSEGVLAGELKHGVLALVDENLPIIAFGTRDSLFPKVVSSIEQVTARKGHPIIICNENDEVWAQKSKSIDLQTLEVPQTVDCLQGLINIIPLQLMSYWLAVNKGIDVDFPRNLAKSVTVE
  
Inhibitor
Name:
BDBM86764
Synonyms:
N3-Oxoacyl derivative, 3
Type:
Small organic molecule
Emp. Form.:
C13H14N2O4
Mol. Mass.:
262.2613
SMILES:
N[C@@H](CNC(=O)\C=C\C(=O)c1ccccc1)C(O)=O |r|
Structure:
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