Reaction Details
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Glutamine--fructose-6-phosphate transaminase (isomerizing)
Ligand
BDBM86765
Substrate
n/a
Meas. Tech.
Inhibition Assay
Ki
1.5200e+7±n/a nM
IC50
5.600e+6± 2.00e+5 nM
Citation
Jedrzejczak, R; Wojciechowski, M; Andruszkiewicz, R; Sowinski, P; Kot-Wasik, A; Milewski, S Inactivation of glucosamine-6-phosphate synthase by N3-oxoacyl derivatives of L-2,3-diaminopropanoic acid. Chembiochem 13:85-96 (2012) [PubMed] Article More Info.:
Target
Name:
Glutamine--fructose-6-phosphate transaminase (isomerizing)
Synonyms:
Glucosamine-6-phosphate synthase
Type:
Enzyme
Mol. Mass.:
80044.29
Organism:
Saccharomyces cerevisiae (Baker's yeast)
Description:
A6ZZL3
Residue:
717
Sequence:
MCGIFGYCNYLVERSRGEIIDTLVDGLQRLEYRGYDSTGIAIDGDEADSTFIYKQIGKVSALKEEITKQNPNRDVTFVSHCGIAHTRWATHGRPEQVNCHPQRSDPEDQFVVVHNGIITNFRELKTLLINKGYKFESDTDTECIAKLYLHLYNTNLQNGHDLDFHELTKLVLLELEGSYGLLCKSCHYPNEVIATRKGSPLLIGVKSEKKLKVDFVDVEFPEENAGQPEIPLKSNNKSFGLGPKKAREFEAGSQNANLLPIAANEFNLRHSQSRAFLSEDGSPTPVEFFVSSDAASVVKHTKKVLFLEDDDLAHIYDGELHIHRSRREVGASMTRSIQTLEMELAQIMKGPYDHFMQKEIYEQPESTFNTMRGRIDYENNKVILGGLKAWLPVVRRARRLIMIACGTSYHSCLATRAIFEELSDIPVSVELASDFLDRKCPVFRDDVCVFVSQSGETADTMLALNYCLERGALTVGIVNSVGSSISRVTHCGVHINAGPEIGVASTKAYTSQYIALVMFALSLSDDRVSKIDRRIEIIQGLKLIPGQIKQVLKLEPRIKKLCATELKDQKSLLLLGRGYQFAAALEGALKIKEISYMHSEGVLAGELKHGVLALVDENLPIIAFGTRDSLFPKVVSSIEQVTARKGHPIIICNENDEVWAQKSKSIDLQTLEVPQTVDCLQGLINIIPLQLMSYWLAVNKGIDVDFPRNLAKSVTVE
Inhibitor
Name:
BDBM86765
Synonyms:
N3-Oxoacyl derivative, 4
Type:
Small organic molecule
Emp. Form.:
C8H12N2O4
Mol. Mass.:
200.1919
SMILES:
CC(=O)C=CC(=O)NC[C@H](N)C(O)=O |r,w:4.4|
Structure:
