Reaction Details
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Glutamine--fructose-6-phosphate transaminase (isomerizing)
Ligand
BDBM86766
Substrate
n/a
Meas. Tech.
Inhibition Assay
Ki
4.50e+5±n/a nM
IC50
6.60e+5± 5.0e+4 nM
Citation
Jedrzejczak, R; Wojciechowski, M; Andruszkiewicz, R; Sowinski, P; Kot-Wasik, A; Milewski, S Inactivation of glucosamine-6-phosphate synthase by N3-oxoacyl derivatives of L-2,3-diaminopropanoic acid. Chembiochem 13:85-96 (2012) [PubMed] Article More Info.:
Target
Name:
Glutamine--fructose-6-phosphate transaminase (isomerizing)
Synonyms:
Glucosamine-6-phosphate synthase
Type:
Enzyme
Mol. Mass.:
80044.29
Organism:
Saccharomyces cerevisiae (Baker's yeast)
Description:
A6ZZL3
Residue:
717
Sequence:
MCGIFGYCNYLVERSRGEIIDTLVDGLQRLEYRGYDSTGIAIDGDEADSTFIYKQIGKVSALKEEITKQNPNRDVTFVSHCGIAHTRWATHGRPEQVNCHPQRSDPEDQFVVVHNGIITNFRELKTLLINKGYKFESDTDTECIAKLYLHLYNTNLQNGHDLDFHELTKLVLLELEGSYGLLCKSCHYPNEVIATRKGSPLLIGVKSEKKLKVDFVDVEFPEENAGQPEIPLKSNNKSFGLGPKKAREFEAGSQNANLLPIAANEFNLRHSQSRAFLSEDGSPTPVEFFVSSDAASVVKHTKKVLFLEDDDLAHIYDGELHIHRSRREVGASMTRSIQTLEMELAQIMKGPYDHFMQKEIYEQPESTFNTMRGRIDYENNKVILGGLKAWLPVVRRARRLIMIACGTSYHSCLATRAIFEELSDIPVSVELASDFLDRKCPVFRDDVCVFVSQSGETADTMLALNYCLERGALTVGIVNSVGSSISRVTHCGVHINAGPEIGVASTKAYTSQYIALVMFALSLSDDRVSKIDRRIEIIQGLKLIPGQIKQVLKLEPRIKKLCATELKDQKSLLLLGRGYQFAAALEGALKIKEISYMHSEGVLAGELKHGVLALVDENLPIIAFGTRDSLFPKVVSSIEQVTARKGHPIIICNENDEVWAQKSKSIDLQTLEVPQTVDCLQGLINIIPLQLMSYWLAVNKGIDVDFPRNLAKSVTVE
Inhibitor
Name:
BDBM86766
Synonyms:
N3-Oxoacyl derivative, 1
Type:
Small organic molecule
Emp. Form.:
C13H14N2O5
Mol. Mass.:
278.2607
SMILES:
N[C@@H](CNC(=O)[C@@H]1O[C@H]1C(=O)c1ccccc1)C(O)=O |r|
Structure:
