Reaction Details Report a problem with these data
Target
Polyphenol oxidase 2
Ligand
BDBM87065
Substrate
n/a
Meas. Tech.
Enzyme Assay
pH
6.8±0
Temperature
298.15±0 K
IC50
4.0247e+5±n/a nM
Citation
 Liu, SH; Chu, IM; Pan, IH Effects of hydroxybenzyl alcohols on melanogenesis in melanocyte-keratinocyte co-culture and monolayer culture of melanocytes. J Enzyme Inhib Med Chem 23:526-34 (2008) [PubMed]  Article 
Target
Name:
Polyphenol oxidase 2
Synonyms:
Monophenol monooxygenase | Monophenol oxidase | PPO2 | PPO2_AGABI | Tyrosinase
Type:
Protein
Mol. Mass.:
63923.66
Organism:
Agaricus bisporus (Common mushroom)
Description:
O42713
Residue:
556
Sequence:
MSLIATVGPTGGVKNRLNIVDFVKNEKFFTLYVRSLELLQAKEQHDYSSFFQLAGIHGLPFTEWAKERPSMNLYKAGYCTHGQVLFPTWHRTYLSVLEQILQGAAIEVAKKFTSNQTDWVQAAQDLRQPYWDWGFELMPPDEVIKNEEVNITNYDGKKISVKNPILRYHFHPIDPSFKPYGDFATWRTTVRNPDRNRREDIPGLIKKMRLEEGQIREKTYNMLKFNDAWERFSNHGISDDQHANSLESVHDDIHVMVGYGKIEGHMDHPFFAAFDPIFWLHHTNVDRLLSLWKAINPDVWVTSGRNRDGTMGIAPNAQINSETPLEPFYQSGDKVWTSASLADTARLGYSYPDFDKLVGGTKELIRDAIDDLIDERYGSKPSSGARNTAFDLLADFKGITKEHKEDLKMYDWTIHVAFKKFELKESFSLLFYFASDGGDYDQENCFVGSINAFRGTAPETCANCQDNENLIQEGFIHLNHYLARDLESFEPQDVHKFLKEKGLSYKLYSRGDKPLTSLSVKIEGRPLHLPPGEHRPKYDHTQARVVFDDVAVHVIN
  
Inhibitor
Name:
BDBM87065
Synonyms:
3HBA | 4-[4-(4-methylphenyl)sulfonyl-2-(3,4,5-trimethoxyphenyl)-1,3-oxazol-5-yl]morpholine | 4-[4-(4-methylphenyl)sulfonyl-2-(3,4,5-trimethoxyphenyl)-5-oxazolyl]morpholine | 4-[4-(Toluene-4-sulfonyl)-2-(3,4,5-trimethoxy-phenyl)-oxazol-5-yl]-morpholine | 4-[4-tosyl-2-(3,4,5-trimethoxyphenyl)oxazol-5-yl]morpholine | MLS000077234 | SMR000012143 | cid_651601
Type:
Small organic molecule
Emp. Form.:
C23H26N2O7S
Mol. Mass.:
474.527
SMILES:
COc1cc(cc(OC)c1OC)-c1nc(c(o1)N1CCOCC1)S(=O)(=O)c1ccc(C)cc1
Structure:
Search PDB for entries with ligand similarity: