Reaction Details Report a problem with these data
Target
Tegument protein VP16
Ligand
BDBM67666
Substrate
n/a
Meas. Tech.
Counterscreen for inhibitors of the Steroid Receptor Coactivator 3 (SRC3; NCOA3)
IC50
12198±n/a nM
Citation
 PubChem, PC Counterscreen for inhibitors of the Steroid Receptor Coactivator 3 (SRC3; NCOA3): Luminescence-based cell-based high throughput dose response assay to identify inhibitors of the Herpes Virus Virion Protein 16 (VP16) PubChem Bioassay (2012)[AID] 
Target
Name:
Tegument protein VP16
Synonyms:
Alpha trans-inducing protein (VP16) | VP16_HHV11 | transactivating tegument protein VP16
Type:
PROTEIN
Mol. Mass.:
54325.13
Organism:
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus1)
Description:
EBI_100271
Residue:
490
Sequence:
MDLLVDELFADMNADGASPPPPRPAGGPKNTPAAPPLYATGRLSQAQLMPSPPMPVPPAALFNRLLDDLGFSAGPALCTMLDTWNEDLFSALPTNADLYRECKFLSTLPSDVVEWGDAYVPERTQIDIRAHGDVAFPTLPATRDGLGLYYEALSRFFHAELRAREESYRTVLANFCSALYRYLRASVRQLHRQAHMRGRDRDLGEMLRATIADRYYRETARLARVLFLHLYLFLTREILWAAYAEQMMRPDLFDCLCCDLESWRQLAGLFQPFMFVNGALTVRGVPIEARRLRELNHIREHLNLPLVRSAATEEPGAPLTTPPTLHGNQARASGYFMVLIRAKLDSYSSFTTSPSEAVMREHAYSRARTKNNYGSTIEGLLDLPDDDAPEEAGLAAPRLSFLPAGHTRRLSTAPPTDVSLGDELHLDGEDVAMAHADALDDFDLDMLGDGDSPGPGFTPHDSAPYGALDMADFEFEQMFTDALGIDEYGG
  
Inhibitor
Name:
BDBM67666
Synonyms:
(E)-3-(dimethylamino)-1-(3-phenyl-2,1-benzoxazol-5-yl)-2-propen-1-one | (E)-3-(dimethylamino)-1-(3-phenyl-2,1-benzoxazol-5-yl)prop-2-en-1-one | (E)-3-(dimethylamino)-1-(3-phenylanthranil-5-yl)prop-2-en-1-one | 3-(dimethylamino)-1-(3-phenyl-2,1-benzisoxazol-5-yl)-2-propen-1-one | MLS001166481 | SMR000549693 | cid_1483761
Type:
Small organic molecule
Emp. Form.:
C18H16N2O2
Mol. Mass.:
292.3318
SMILES:
CN(C)\C=C\C(=O)c1ccc2noc(-c3ccccc3)c2c1
Structure:
Search PDB for entries with ligand similarity: